914226-80-5

Basic information

• Product Name: 1-benzyl-N-isopropylpiperidine-4-carboxamide
• Synonyms: 1-benzyl-N-isopropylpiperidine-4-carboxamide
• CAS NO: 914226-80-5
• Molecular Weight: 260.379
• Mol File: 914226-80-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-benzyl-N-isopropylpiperidine-4-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-N-isopropylpiperidine-4-carboxamide(914226-80-5)
• EPA Substance Registry System: 1-benzyl-N-isopropylpiperidine-4-carboxamide(914226-80-5)

Safety Data

• Hazardous Substances Data: 914226-80-5(Hazardous Substances Data)

Upstream product

• 102125-62-2 N-isopropylpiperidine-4-carboxamide 
• 100-44-7 benzyl chloride 
• 1016716-09-8 tert-butyl 4-(isopropylcarbamoyl)piperidine-1-carboxylate 
• 10315-07-8 N-benzylpiperidine-4-carboxylic acid 
• 75-31-0 isopropylamine 
• 84358-13-4 N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid 

Relevant articles and documents

Improving selectivity preserving affinity: New piperidine-4-carboxamide derivatives as effective sigma-1-ligands

We report the design, synthesis and binding evaluation against 1 and 2 receptors of a series of new piperidine-4-carboxamide derivatives variously substituted on the amide nitrogen atom. Specifically, we assessed the effects exerted on receptor affinity by substituting the N-benzylcarboxamide group present on a series of compounds previously synthesized in our laboratory with different cyclic or linear moieties. The synthesized compounds 2a-o were tested to estimate their affinity and selectivity toward 1 and2 receptors. Very high 1 affinity (Ki Combining double low line 3.7 nM) and Ki2/Ki1 selectivity ratio (351) were found for the tetrahydroquinoline derivative 2k, featuring a 4-chlorobenzyl moiety linked to the piperidine nitrogen atom.