914347-52-7

Basic information

• Product Name: 2-AMINO-5-BROMO-4-DIMETHOXYMETHYLPYRIMIDINE
• Synonyms: 2-AMINO-5-BROMO-4-DIMETHOXYMETHYLPYRIMIDINE;5-BroMo-4-(diMethoxyMethyl)pyriMidin-2-aMine;5-Bromo-4-(dimethoxymethyl)
• CAS NO: 914347-52-7
• Molecular Formula: C7H10BrN3O2
• Molecular Weight: 248.08
• Product Categories: Heterocycle-Pyrimidine series
• Mol File: 914347-52-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 354.8°C at 760 mmHg
• Flash Point: 168.4°C
• Appearance: /
• Density: 1.578g/cm³
• Vapor Pressure: 3.27E-05mmHg at 25°C
• Refractive Index: 1.576
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 1.51±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-5-BROMO-4-DIMETHOXYMETHYLPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5-BROMO-4-DIMETHOXYMETHYLPYRIMIDINE(914347-52-7)
• EPA Substance Registry System: 2-AMINO-5-BROMO-4-DIMETHOXYMETHYLPYRIMIDINE(914347-52-7)

Safety Data

• Hazardous Substances Data: 914347-52-7(Hazardous Substances Data)

Usage

General Description

2-AMINO-5-BROMO-4-DIMETHOXYMETHYLPYRIMIDINE is a chemical compound with the molecular formula C7H10BrN3O2. It is a pyrimidine derivative with an amino group and bromine atom attached to the pyrimidine ring, and two dimethoxymethyl groups on the 4-carbon position. 2-AMINO-5-BROMO-4-DIMETHOXYMETHYLPYRIMIDINE is commonly used in pharmaceutical and agrochemical industries for its potential biological activities and its role as a building block for the synthesis of various organic compounds. Its properties and specific uses make it a valuable chemical in the development of new drugs and pesticides.

InChI:InChI=1/C7H10BrN3O2/c1-12-6(13-2)5-4(8)3-10-7(9)11-5/h3,6H,1-2H3,(H2,9,10,11)

Upstream product

• 165807-05-6 4-(dimethoxymethyl)pyrimidin-2-amine 
• 67751-23-9 (E)-4-(dimethylamino)-1,1-dimethoxybut-3-en-2-one 
• 6342-56-9 Pyruvic aldehyde dimethyl acetal 

Relevant articles and documents

A Conformational Restriction Strategy for the Identification of a Highly Selective Pyrimido-pyrrolo-oxazine mTOR Inhibitor

The mechanistic target of rapamycin (mTOR) plays a pivotal role in growth and tumor progression and is an attractive target for cancer treatment. ATP-competitive mTOR kinase inhibitors (TORKi) have the potential to overcome limitations of rapamycin derivatives in a wide range of malignancies. Herein, we exploit a conformational restriction approach to explore a novel chemical space for the generation of TORKi. Structure-activity relationship (SAR) studies led to the identification of compound 12b with a ～450-fold selectivity for mTOR over class I PI3K isoforms. Pharmacokinetic studies in male Sprague Dawley rats highlighted a good exposure after oral dosing and a minimum brain penetration. CYP450 reactive phenotyping pointed out the high metabolic stability of 12b. These results identify the tricyclic pyrimido-pyrrolo-oxazine moiety as a novel scaffold for the development of highly selective mTOR inhibitors for cancer treatment.