914619-02-6Relevant articles and documents
Synthesis and structural activity relationship of 11β-HSD1 inhibitors with novel adamantane replacements
Yeh, Vince S.C.,Kurukulasuriya, Ravi,Madar, David,Patel, Jyoti R.,Fung, Steven,Monzon, Katina,Chiou, William,Wang, Jiahong,Jacobson, Peer,Sham, Hing L.,Link
, p. 5408 - 5413 (2006)
A series of structurally novel and metabolically stable bridged bicyclic carbocycle and heterocycle adamantane replacements have been synthesized and biologically evaluated. Several of these compounds exhibit excellent human and mouse 11β-HSD1 potency and