91473-32-4Relevant articles and documents
Ti(III)-MEDIATED REDUCTIONS OF N-HYDROXY IMIDAZOLES TO 1-PROTIO-2,4(5)-DISUBSTITUTED DERIVATIVES
Lipshutz, Bruce H.,Morey, Matthew C.
, p. 1319 - 1320 (1984)
N-Hydroxy imidazoles are converted via TiCl3 in MeOH/H2O to N-protio derivatives, useful precursors of chiral amino acids.
A One Step Synthesis of 4-Substituted Imidazoles. An Important Observation When N-Alkylating Imidazoles
Whitten, Jeffrey P.,Matthews, Donald P.,McCarthy, James R.,Barbuch, Robert J.
, p. 1845 - 1847 (2007/10/02)
Imidazoles substituted in the 2-position with methyl, 1e, phenyl, 1a, 2-imidazole, 1b-d, or t-butyldiphenylsilyl, 1f, react with soft electrophiles 2 to give modest yields of 4(5)-C-alkylated-imidazoles 3 and N-alkylated products 5.These two products are readily separated by flash chromatography.