91486-80-5

Basic information

• Product Name: Isoquinoline, 3-(3,4-dimethoxyphenyl)-3,4-dihydro-6,7-dimethoxy-1-phenyl-
• CAS NO: 91486-80-5
• Molecular Formula: C25H25NO4
• Molecular Weight: 403.478
• Mol File: 91486-80-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Isoquinoline, 3-(3,4-dimethoxyphenyl)-3,4-dihydro-6,7-dimethoxy-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Isoquinoline, 3-(3,4-dimethoxyphenyl)-3,4-dihydro-6,7-dimethoxy-1-phenyl-(91486-80-5)
• EPA Substance Registry System: Isoquinoline, 3-(3,4-dimethoxyphenyl)-3,4-dihydro-6,7-dimethoxy-1-phenyl-(91486-80-5)

Safety Data

• Hazardous Substances Data: 91486-80-5(Hazardous Substances Data)

Upstream product

• 5471-40-9 3,4,3',4'-tetramethoxy-bibenzyl-α-ylamine 
• 100-52-7 benzaldehyde 
• 91486-64-5 1-Phenyl-3-(3,4-dimethoxyphenyl)-6,7-dimethoxytetrahydroisoquinoline 
• 65-85-0 benzoic acid 

Relevant articles and documents

DETERMINATION OF THE STEREOCHEMISTRY OF 1-SUBSTITUTED 3-ARYLTETRAHYDROISOQUINOLINES BY 1H NMR SPECTROSCOPY

The cis-1,3-disubstituted tetrahydroisoquinolines 2 can be obtained in a highly diastereoselective fashion through Pictet-Spengler cyclization of the 1,2-bis(3,4-dimethoxyphenyl)-ethylamine with aliphatic and aromatic aldehydes under acidic conditions.However, the epimeric trans-1,3-disubstituted tetrahydroisoquinolines 3 are also isolated as minor products.The stereochemistry of the tetrahydroisoquinolines was unambiguously assigned on the basis of the 1H NMR data, and are supported by difference NOE measurements.

Dehydrogenation Reactions of 1-Substituted-3-Aryltetrahydroisoquinoline Derivatives

The 1-substituted-3-aryltetrahydroisoquinolines I have been converted into the corresponding 3,4-dihydro- or isoquinoline derivatives by treatment with several oxidizing agents: iodine in ethanol, palladium on carbon, DDQ and Fremy's salt.The oxidation re