91486-81-6

Basic information

• Product Name: Isoquinoline, 1,3-bis(3,4-dimethoxyphenyl)-3,4-dihydro-6,7-dimethoxy-
• CAS NO: 91486-81-6
• Molecular Formula: C27H29NO6
• Molecular Weight: 463.53
• Mol File: 91486-81-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Isoquinoline, 1,3-bis(3,4-dimethoxyphenyl)-3,4-dihydro-6,7-dimethoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Isoquinoline, 1,3-bis(3,4-dimethoxyphenyl)-3,4-dihydro-6,7-dimethoxy-(91486-81-6)
• EPA Substance Registry System: Isoquinoline, 1,3-bis(3,4-dimethoxyphenyl)-3,4-dihydro-6,7-dimethoxy-(91486-81-6)

Safety Data

• Hazardous Substances Data: 91486-81-6(Hazardous Substances Data)

Upstream product

• 5471-40-9 3,4,3',4'-tetramethoxy-bibenzyl-α-ylamine 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 91486-65-6 1,3-Bis-(3,4-dimethoxy-phenyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline 

Relevant articles and documents

DETERMINATION OF THE STEREOCHEMISTRY OF 1-SUBSTITUTED 3-ARYLTETRAHYDROISOQUINOLINES BY 1H NMR SPECTROSCOPY

The cis-1,3-disubstituted tetrahydroisoquinolines 2 can be obtained in a highly diastereoselective fashion through Pictet-Spengler cyclization of the 1,2-bis(3,4-dimethoxyphenyl)-ethylamine with aliphatic and aromatic aldehydes under acidic conditions.However, the epimeric trans-1,3-disubstituted tetrahydroisoquinolines 3 are also isolated as minor products.The stereochemistry of the tetrahydroisoquinolines was unambiguously assigned on the basis of the 1H NMR data, and are supported by difference NOE measurements.