914929-95-6

Basic information

• Product Name: N-(2-bromophenyl)-2-(1H-indol-3-yl)acetamide
• Synonyms: N-(2-bromophenyl)-2-(1H-indol-3-yl)acetamide
• CAS NO: 914929-95-6
• Molecular Weight: 329.196
• Mol File: 914929-95-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: N-(2-bromophenyl)-2-(1H-indol-3-yl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-bromophenyl)-2-(1H-indol-3-yl)acetamide(914929-95-6)
• EPA Substance Registry System: N-(2-bromophenyl)-2-(1H-indol-3-yl)acetamide(914929-95-6)

Safety Data

• Hazardous Substances Data: 914929-95-6(Hazardous Substances Data)

Upstream product

• 87-51-4 indole-3-acetic acid 
• 615-36-1 2-bromoaniline 

Downstream Products

• 142273-18-5 paullone 
• 52190-18-8 2-(1H-indol-3-yl)-N-phenyl acetamide 

Relevant articles and documents

Breaking and Making of Rings: A Method for the Preparation of 4-Quinolone-3-carboxylic Acid Amides and the Expensive Drug Ivacaftor

A simple and convenient method to access 4-quinolone-3-carboxylic acid amides from indole-3-acetic acid amides through one-pot oxidative cleavage of the indole ring followed by condensation (Witkop-Winterfeldt type oxidation) was explored. The scope of the method was confirmed with more than 20 examples and was successfully applied to the synthesis of the drug Ivacaftor, the most expensive drug on the market.

Use of indole compounds in radix isatidis, and derivatives thereof in preparation of anti-influenza virus medicines

The invention discloses an application of indole compounds extracted from radix isatidis and represented by general formula (I), and derivatives and pharmaceutically acceptable salts thereof in the preparation of anti-influenza virus medicines or healthcare products, and discloses a preparation method of the compounds, and an application of medicinal compositions containing the compounds in the preparation of the anti-influenza virus medicines or healthcare products.

PROCESS FOR THE SYNTHESIS OF IVACAFTOR AND RELATED COMPOUNDS

The present patent discloses a novel one pot two-step process for the synthesis of ivacaftor and related compounds of [Formula (I)], wherein R1, R2, R3, R4, R5, R6, R7 and Ar1 are as described above; its tautomers or pharmaceutically acceptable salts thereof starting from indole acetic acid amides.