915092-85-2Relevant articles and documents
Synthesis and evaluation of atorvastatin esters as prodrugs metabolically activated by human carboxylesterases
Mizoi, Kenta,Takahashi, Masato,Haba, Masami,Hosokawa, Masakiyo
supporting information, p. 921 - 923 (2016/05/24)
We synthesized 11 kinds of prodrug with an esterified carboxylic acid moiety of atorvastatin in moderate to high yields. We discovered that they underwent metabolic activation specifically by the human carboxylesterase 1 (CES1) isozyme. The results sugges