915093-13-9

Basic information

• Product Name: ethyl 2,2-difluoro-3-phenyl-3-(phenylamino)propionate
• Synonyms: ethyl 2,2-difluoro-3-phenyl-3-(phenylamino)propionate
• CAS NO: 915093-13-9
• Molecular Weight: 305.324
• Mol File: 915093-13-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: ethyl 2,2-difluoro-3-phenyl-3-(phenylamino)propionate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2,2-difluoro-3-phenyl-3-(phenylamino)propionate(915093-13-9)
• EPA Substance Registry System: ethyl 2,2-difluoro-3-phenyl-3-(phenylamino)propionate(915093-13-9)

Safety Data

• Hazardous Substances Data: 915093-13-9(Hazardous Substances Data)

Upstream product

• 667-27-6 Ethyl bromodifluoroacetate 
• 538-51-2 benzylidene phenylamine 
• 205865-67-4 α-(trimethylsilyl)difluoroacetic acid ethyl ester 

Relevant articles and documents

Indium-promoted reformatsky reaction: A straightforward access to β-amino and β-hydroxy α,α-difluoro carbonyl compounds

A versatile and practical methodology to access β-amino and β-hydroxy α,α-difluoro carbonyl compounds using indium metal is described. This methodology has been successfully applied to a broad range of substrates including aldehydes, ketones, and imines,

Ethyl difluoro(trimethylsilyl)acetate and difluoro(trimethylsilyl) acetamides - Precursors of 3,3-difluoroazetidinones

Difluoro(trimethylsilyl)acetamides 7 have been prepared from chlorodifluoroacetamides 5 by electrochemical silylation. When condensed with carbonyl compounds, they were shown to be precursors of 2,2-difluoro-3- hydroxyacetamides 8. N-(p-Methoxyphenyl)-2,2-difluoro-3-hydroxy-4- methylvaleramide (8a) has been converted into the correspending 3,3-difluoroazetidinone 9a. This new route to 3,3-difluoroazetidinones is shown to be an alternative to the one utilizing the condensation of ethyl difluoro(trimethylsilyl)acetate with imines. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.