915140-06-6

Basic information

• Product Name: 4-PYRIDINECARBOXYLIC ACID, 2-(HYDROXYMETHYL)-
• Synonyms: 4-PYRIDINECARBOXYLIC ACID, 2-(HYDROXYMETHYL)-;2-Hydroxymethylisonicotinic acid
• CAS NO: 915140-06-6
• Molecular Formula: C7H7NO3
• Molecular Weight: 153.13538
• Mol File: 915140-06-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.404
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 4-PYRIDINECARBOXYLIC ACID, 2-(HYDROXYMETHYL)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PYRIDINECARBOXYLIC ACID, 2-(HYDROXYMETHYL)-(915140-06-6)
• EPA Substance Registry System: 4-PYRIDINECARBOXYLIC ACID, 2-(HYDROXYMETHYL)-(915140-06-6)

Safety Data

• Hazardous Substances Data: 915140-06-6(Hazardous Substances Data)

Usage

General Description

4-Pyridinecarboxylic acid, 2-(hydroxymethyl)-, often referred to as Hydroxymethyl nicotinic acid, is a chemical compound belonging to the pyridine and pyridine derivatives class. It combines a carboxylic acid and hydroxyl group attached to a methyl group in its structure. This relatively stable compound is useful in the field of chemistry, particularly in medicinal or pharmaceutical applications, due to its involvement in several biological activities. Its properties can be manipulated when combined with other chemicals to produce specific therapeutic effects. Adequate precautions should be taken while handling this chemical due to its potential hazards.

Upstream product

• 31804-60-1 ethyl 2-(hydroxymethyl)pyridine-4-carboxylate 
• 499-80-9 pyridine-2,4-dicarboxylic acid 
• 142074-49-5 2-(ethoxycarbonyl)isonicotinic acid 

Downstream Products

• 51454-64-9 2-Chloromethyl-4-cyanopyridine 
• 84589-39-9 2-hydroxymethyl-4-pyridinecarboxamide 

Relevant articles and documents

Zinc and Cadmium Complexes of Pyridinemethanol Carboxylates: Metal Carboxylate Zwitterions and Metal–Organic Frameworks

The heterofunctional lactone furo[3,4-b]pyridin-5(7H)-one (L1) undergoes a coordination-induced ring-opening reaction with Zn(NO3)2 ? 6H2O to yield the zwitterionic [Zn(L1′)2(H2O)2] (1, L1′=2-(hydroxymethyl)nicotinate) with an uncoordinated carboxylate. The same reaction with Cd(NO3)2 ? 4H2O provides a two-dimensional (2D) network of [Cd(L1′)2]n (3) with the carboxylates coordinated to cadmium(II) propagating the assembly. The corresponding reactions of Zn(NO3)2 ? 6H2O and Cd(NO3)2 ? 4H2O with 2-(hydroxymethyl)isonicotinic acid (HL2) generated zwitterionic [Zn(L2)2(H2O)2] (2) and a 2D network [Cd(L2)2]n?nDMF (4, DMF=N,N′-dimethylformamide), respectively. Complexes 1–4 are weakly emissive, giving ligand-centered emissions at 409 nm (1), 412/436 nm (2), 404 nm (3), and 412/436 nm (4) in CHCl3 solutions upon excitation at 330 nm. This work points to the potential of using ‘hidden’ functionalities widely found in small organic molecules and natural products for the construction of coordination complexes with new functionality and potential applications.

Isolation of first row transition metal-carboxylate zwitterions

Zwitterionic 3d metal carboxylates of Zn(ii), Cu(ii), Ni(ii) and Co(ii) have been isolated and structurally authenticated by X-ray crystallography. A series of 2-hydroxymethylpyridine-carboxylate ligands with different sizes and shapes demonstrate variabl