91517-26-9

Basic information

• Product Name: 2-(4-METHOXY-PHENYL)-PIPERAZINE
• Synonyms: 2-(4-METHOXY-PHENYL)-PIPERAZINE;2-(4-Methoxyphenyl)piperazine95%;2-(4-methoxyphenyl)piperazine acetate;2-(4-Methoxyphenyl)piperazine 2HCl
• CAS NO: 91517-26-9
• Molecular Formula: C₁₁H₁₆N₂O
• Molecular Weight: 192.26
• Mol File: 91517-26-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 55-63℃
• Boiling Point: 331.5 °C at 760 mmHg
• Flash Point: 131.5 °C
• Appearance: /
• Density: 1.029g/cm³
• Vapor Pressure: 0.000155mmHg at 25°C
• Refractive Index: 1.514
• Storage Temp.: 2-8°C(protect from light)
• PKA: 8.84±0.40(Predicted)
• Sensitive: Air Sensitive
• CAS DataBase Reference: 2-(4-METHOXY-PHENYL)-PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-METHOXY-PHENYL)-PIPERAZINE(91517-26-9)
• EPA Substance Registry System: 2-(4-METHOXY-PHENYL)-PIPERAZINE(91517-26-9)

Safety Data

• Hazard Codes: Xi,T
• Statements: 25-38-41
• Safety Statements: 26-39-45
• RIDADR: UN 2811 6.1 / PGIII
• HazardClass: IRRITANT
• Hazardous Substances Data: 91517-26-9(Hazardous Substances Data)

Usage

General Description

2-(4-Methoxy-Phenyl)-Piperazine, also known as MeOPP, is a psychoactive compound of the phenylpiperazine group. With structural similarity to other psychoactive substances, it is formulated using a substituted base of piperazine. The '4-Methoxy' in the name implies the presence of a methoxy functional group that is attached to the phenyl ring at the R4 position. Its effects provoke noticeable stimulation and euphoria which can lead to side effects like anxiety or panic. Use of this substance, especially in high concentrations, is discouraged due to the potential psychological and physical side effects.

InChI:InChI=1/C11H16N2O/c1-14-10-4-2-9(3-5-10)11-8-12-6-7-13-11/h2-5,11-13H,6-8H2,1H3

Upstream product

• 107-15-3 ethylenediamine 
• 1076-95-5 p-methoxyphenylglyoxal 
• 637-69-4 4-Methoxystyrene 
• 1421004-97-8 C₂₅H₂₈N₂O 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 40140-16-7 ethyl (p-methoxyphenyl)oxoacetate 
• 85606-89-9 3-(4-methoxyphenyl)-5,6-dihydropyrazin-2(1H)-one 

Downstream Products

• 137684-49-2 (RS)-1-cyclopropyl-3-ethoxycarbonyl-7-fluoro-8-[3-(4-methoxyphenyl)-1-piperazinyl]-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine 

Relevant articles and documents

Discovery of novel 2-(3-phenylpiperazin-1-yl)-pyrimidin-4-ones as glycogen synthase kinase-3β inhibitors

We herein describe the results of further evolution of glycogen synthase kinase (GSK)-3β inhibitors from our promising compounds containing a 2-phenylmorpholine moiety. Transformation of the morpholine moiety into a piperazine moiety resulted in potent GSK-3β inhibitors. SAR studies focused on the phenyl moiety revealed that a 4-fluoro-2-methoxy group afforded potent inhibitory activity toward GSK-3β. Based on docking studies, new hydrogen bonding between the nitrogen atom of the piperazine moiety and the oxygen atom of the main chain of Gln185 has been indicated, which may contribute to increased activity compared with that of the corresponding phenylmorpholine analogues. Effect of the stereochemistry of the phenylpiperazine moiety is also discussed.

2, 3, 6-TRISUBSTITUTED-4-PYRIMIDONE DERIVATIVES

A pyrimidone derivative having tau protein kinase 1 inhibitory activity which is represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof; useful for prventive and/or therapeutic treatment of diseass such as neurodegenerative diseases (e.g. Alzheimer disease); wherein Q represents CH or nitrogen atom; R represents a C1-C12 alkyl group; the ring of Formula (I): represents piperazine ring or piperidine ring; each X independently represents a C1-C8 alkyl group, an optionally partially hydrogenated C6-C10 aryl ring, an indan ring or the like; m represents an integer of 1 to 3; each Y independently represents a halogen atom, a hydroxy group, a cyano group, a C1-C6 alkyl group or the like; n represents an integer of 0 to 8; when X and Y or two Y groups are attached on the same carbon atom, they may combine to each other to form a C2-C6 alkylene group.