91520-00-2

Basic information

• Product Name: 8-METHOXY-2H-CHROMEN-3(4H)-ONE
• Synonyms: 8-METHOXY-2H-CHROMEN-3(4H)-ONE;8-METHOXYCHROMAN-3-ONE;8-Methoxy-3-chromanone
• CAS NO: 91520-00-2
• Molecular Formula: C₁₀H₁₀O₃
• Molecular Weight: 178.18
• Mol File: 91520-00-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 321.7°C at 760 mmHg
• Flash Point: 139.4°C
• Appearance: /
• Density: 1.205g/cm³
• Vapor Pressure: 0.000292mmHg at 25°C
• Refractive Index: 1.546
• CAS DataBase Reference: 8-METHOXY-2H-CHROMEN-3(4H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 8-METHOXY-2H-CHROMEN-3(4H)-ONE(91520-00-2)
• EPA Substance Registry System: 8-METHOXY-2H-CHROMEN-3(4H)-ONE(91520-00-2)

Safety Data

• Hazardous Substances Data: 91520-00-2(Hazardous Substances Data)

Usage

General Description

8-Methoxy-2H-chromen-3(4H)-one, also known as isopsoralen, is a natural chemical compound found in certain plants such as Psoralea corylifolia. It belongs to the class of compounds known as coumarins, which are known for their various biological activities. Isopsoralen has been studied for its potential pharmacological properties such as anti-inflammatory, anti-cancer, and anti-viral activities. It has also been investigated for its potential therapeutic applications in treating skin disorders and as a photosensitizer in photodynamic therapy for cancer. Additionally, isopsoralen has been used in traditional Chinese medicine for its anti-itch and anti-inflammatory effects and has been the subject of numerous research studies due to its promising medicinal properties.

InChI:InChI=1/C10H10O3/c1-12-9-4-2-3-7-5-8(11)6-13-10(7)9/h2-4H,5-6H2,1H3

Upstream product

• 855933-36-7 (2-carboxymethoxy-3-methoxy-phenyl)-acetic acid 
• 108-24-7 acetic anhydride 
• 57543-59-6 8-methoxy-2H-chromene-3-carboxylic acid 
• 57543-69-8 8‐methoxy‐2H‐chromene‐3‐carbonitrile 
• 148-53-8 3-methoxy-2-hydroxybenzaldehyde 
• 16336-25-7 8-methoxy-2H-1-benzopyran 
• 41580-71-6 1-methoxy-2-(prop-2-ynyloxy)benzene 
• 90-05-1 2-methoxy-phenol 

Downstream Products

• 1026839-64-4 Dibenzyl-((R)-8-methoxy-chroman-3-yl)-amine 
• 81486-18-2 Carbonic acid ethyl ester (R)-3-hydroxy-chroman-8-yl ester 
• 104536-79-0 Carbonic acid ethyl ester (S)-3-nitrooxy-chroman-8-yl ester 
• 104536-66-5 Benzenesulfonic acid (R)-8-ethoxycarbonyloxy-chroman-3-yl ester 

Relevant articles and documents

Bifunctional Br?nsted Base Catalyst Enables Regio-, Diastereo-, and Enantioselective Cα-Alkylation of β-Tetralones and Related Aromatic-Ring-Fused Cycloalkanones

The catalytic asymmetric synthesis of both α-substituted and α,α-disubstituted (quaternary) β-tetralones through direct α-functionalization of the corresponding β-tetralone precursor remains elusive. A designed Br?nsted base-squaramide bifunctional catalyst promotes the conjugate addition of either unsubstituted or α-monosubstituted β-tetralones to nitroalkenes. Under these reaction conditions, not only enolization, and thus functionalization, occurs at the α-carbon atom of the β-tetralone exclusively, but adducts including all-carbon quaternary centers are also formed in highly diastereo- and enantioselective manner.

Novel 2-aminotetralin and 3-aminochroman derivatives as selective serotonin 5-HT7 receptor agonists and antagonists

The understanding of the physiological role of the G-protein coupled serotonin 5-HT7 receptor is largely rudimentary. Therefore, selective and potent pharmacological tools will add to the understanding of serotonergic effects mediated through t

CERTAIN BENZO-(PYRANO AND THIOPYRANO)-PYRIDINES, USEFUL AS CNS AGENTS

Disclosed are the compounds of formula I STR1 wherein X represents oxygen or sulfur; ring A is unsubstituted or substituted by one to three identical or different substituents selected from hydroxy, hydroxy-lower alkyl, etherified hydroxy, etherified hydroxy-lower alkyl, acyloxy, acyloxy-lower alkyl, halogen, lower alkyl, trifluoromethyl, amino, mono-and di-lower alkylamino and acylamino; or ring A is substituted by one lower alkylenedioxy; R represents hydrogen, lower alkyl or aryl-lower alkyl; R 1 represents hydrogen, lower alkyl, lower alkylthio-lower alkyl, amino, acylamino, (amino, mono-or di-lower alkylamino)-lower alkyl, carboxy, lower alkoxycarbonyl, carbamoyl or mono-or di-lower alkylcarbamoyl; R 2 to R 5 represent hydrogen or lower alkyl; the dehydro derivatives thereof with a double bond at the 1, 2-position, or at the 1,10b-position in which case R 5 is absent; or a pharmaceutically acceptable salt thereof; methods for their synthesis; pharmaceutical compositions thereof; and use thereof as psychactive agents for the treatment of central nervous system disorders.