915226-39-0

Basic information

• Product Name: (S)-1-N-Boc-3-cyanopiperidine
• Synonyms: 1-Piperidinecarboxylic acid, 3-cyano-, 1,1-dimethylethyl ester, (3S)-;(S)-1-N-Boc-3-cyanopiperidine;(S)-3-Cyanopiperidine-1-carboxylic acid tert-butyl ester;tert-butyl (3S)-3-cyanopiperidine-1-carboxylate
• CAS NO: 915226-39-0
• Molecular Formula: C11H18N2O2
• Molecular Weight: 210.27
• Mol File: 915226-39-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 325.3°C at 760 mmHg
• Flash Point: 150.5°C
• Appearance: /
• Density: 1.07g/cm³
• Vapor Pressure: 0.000232mmHg at 25°C
• Refractive Index: 1.487
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -3.42±0.40(Predicted)
• CAS DataBase Reference: (S)-1-N-Boc-3-cyanopiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-N-Boc-3-cyanopiperidine(915226-39-0)
• EPA Substance Registry System: (S)-1-N-Boc-3-cyanopiperidine(915226-39-0)

Safety Data

• Hazardous Substances Data: 915226-39-0(Hazardous Substances Data)

Usage

General Description

(S)-1-N-Boc-3-cyanopiperidine is a chemical compound with the molecular formula C13H21N3O2. It is a derivative of piperidine with a Boc (tert-butoxycarbonyl) protective group attached to the nitrogen atom and a cyanide group attached to the third carbon atom. (S)-1-N-Boc-3-cyanopiperidine is commonly used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. It is a versatile building block in organic chemistry, particularly in the production of complex molecules such as drugs and agrochemicals. Its unique structure and reactivity make it valuable in the creation of new chemical entities with potential therapeutic applications.

InChI:InChI=1/C11H18N2O2/c1-11(2,3)15-10(14)13-6-4-5-9(7-12)8-13/h9H,4-6,8H2,1-3H3/t9-/m1/s1

Upstream product

• 88466-77-7 (S)-3-carbamoyl-piperidine-1-carboxylic acid tert-butyl ester 
• 88495-54-9 (3S)-1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid 

Downstream Products

• 915226-72-1 (S)-piperidine-3-carbonitrile hydrochloride 
• 915226-64-1 (S)-1-(4-fluoro-benzoyl)-piperidine-3-carbonitrile 
• 915226-65-2 (S)-1-(4-fluoro-benzoyl)-N-hydroxy-piperidine-3-carboxamidine 
• 915226-65-2 (S)-1-(4-fluoro-benzoyl)-N-hydroxy-piperidine-3-carboxamidine 
• 916500-36-2 (S)-3-[5-(4-fluoro-benzyl)-[1,2,4]oxadiazol-3-yl]-piperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Substituted Oxadiazole Derivatives as Positive Allosteric Modulators of Metabotropic Glutamate Receptors

The present invention relates to new compounds which are Oxadiazole derivatives of formula (I) wherein B, P, Q, W, R1 and R2 are defined in the description. Invention compounds are useful in the prevention or treatment of central or peripheral nervous system disorders as well as other disorders modulated by mGluR5 receptors.(I).

NOVEL HETEROCYCLIC COMPOUNDS AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS

The present invention relates to new compounds which are Heterocyclic derivatives of formula (I) wherein A, B, P, X, Y, Q, W, R1 and R2 are defined in the description. Invention compounds are useful for treating central or peripheral nervous system disorders and other disorders which are affected by the neuromodulatory effect of mGluR5 positive allosteric modulators such as cognitive decline and also to treat both positive and negative symptoms in schizophrenia.