91526-17-9Relevant articles and documents
On the preparation of 4-hydroxymethyl-5-methyl-1,3-dioxol-2-one
Alpegiani,Zarini,Perrone
, p. 1277 - 1282 (1992)
A practical and efficient conversion of 4-bromomethyl-5-methyl-1,3-dioxol-2-one 1 into the corresponding carbinol 2, a useful building block for the preparation of prodrugs, is reported.
N-SUBSTITUTED-CYCLIC AMINO DERIVATIVE
-
Page/Page column 159, (2012/05/20)
The present invention provides a compound of formula (I): wherein R1a is optionally substituted C1-6 alkyl, etc.; R1m is hydrogen atom, etc.; G1, G2, G3 and G4 are (i), etc. ((i) G1 is -N(R1b)-, G2 is -CO-, G3 is -C(R1c)(R1d)-, and G4 is oxygen, etc.); R1b is optionally substituted C1-6 alkyl, etc.; R1c and R1d are each independently optionally substituted C1-6 alkyl, etc.; R2 is optionally substituted C1-6 alkyl, etc.; R3a, R3b, R3c, and R3d are each independently a group: -A-B (A is a single bond, etc., B is hydrogen atom, etc.), etc.; n is 1, etc.; R5 is C1-4 alkoxycarbonyl, etc., or a pharmaceutically acceptable salt thereof, which is useful as a renin inhibitor.
A convenient method for the conversion of halides to alcohols
Alexander,Renyer,Veerapanane
, p. 3875 - 3881 (2007/10/03)
The displacement of halides in unactivated primary bromides and iodides, allylic and benzylic primary and secondary bromides, and primary and secondary α-bromoketones by formate, using triethylammonium formate as the formylating agent, followed by acid or base catalyzed hydrolysis has been found to be an efficient method for the conversion of halides to alcohols.