91532-33-1

Basic information

• Product Name: 1-(3-CHLORO-4-FLUOROPHENYL)PIPERAZINE DIHYDROCHLORIDE
• Synonyms: 1-(3-CHLORO-4-FLUOROPHENYL)PIPERAZINE;1-(3-CHLORO-4-FLUOROPHENYL)PIPERAZINE 2HCL;1-(3-CHLORO-4-FLUOROPHENYL)PIPERAZINE DIHYDROCHLORIDE;TIMTEC-BB SBB002997;1-(3-Chloro-4-fluorophenyl)piperazine dihydrochloride 98%;1-(3-Chloro-4-fluorophenyl)piperazinedihydrochloride98%;PIPERAZINE, 1-(3-CHLORO-4-FLUOROPHENYL)-
• CAS NO: 91532-33-1
• Molecular Formula: C₁₀H₁₂ClFN₂
• Molecular Weight: 287.59
• Product Categories: Piperidines, Piperidones, Piperazines
• Mol File: 91532-33-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 208-210°C
• Boiling Point: 341.2°Cat760mmHg
• Flash Point: 160.1°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 8.2E-05mmHg at 25°C
• CAS DataBase Reference: 1-(3-CHLORO-4-FLUOROPHENYL)PIPERAZINE DIHYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-CHLORO-4-FLUOROPHENYL)PIPERAZINE DIHYDROCHLORIDE(91532-33-1)
• EPA Substance Registry System: 1-(3-CHLORO-4-FLUOROPHENYL)PIPERAZINE DIHYDROCHLORIDE(91532-33-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 91532-33-1(Hazardous Substances Data)

Usage

Description

1-(3-CHLORO-4-FLUOROPHENYL)PIPERAZINE DIHYDROCHLORIDE is a chemical compound characterized by a piperazine core to which a 3-chloro-4-fluorophenyl group is attached. It is commonly encountered as a dihydrochloride salt and has been the subject of research for its pharmacological properties, particularly its interactions with serotonin receptors and its potential as a psychoactive substance. 1-(3-CHLORO-4-FLUOROPHENYL)PIPERAZINE DIHYDROCHLORIDE also serves as a building block in the synthesis of pharmaceuticals and has been explored for its possible applications as an antipsychotic and anxiolytic drug.

Uses

Used in Pharmaceutical Synthesis:
1-(3-CHLORO-4-FLUOROPHENYL)PIPERAZINE DIHYDROCHLORIDE is used as a key intermediate in the synthesis of various pharmaceutical compounds, leveraging its structural features to create new drugs with potential therapeutic benefits.
Used in Psychopharmacology Research:
In the field of psychopharmacology, 1-(3-CHLORO-4-FLUOROPHENYL)PIPERAZINE DIHYDROCHLORIDE is used as a research tool to study its interactions with serotonin receptors, which may contribute to understanding its psychoactive properties and potential effects on mood and behavior.
Used in Development of Antipsychotic Drugs:
1-(3-CHLORO-4-FLUOROPHENYL)PIPERAZINE DIHYDROCHLORIDE is being investigated for its potential use as an antipsychotic drug, with the aim of developing new treatments for psychiatric disorders such as schizophrenia and bipolar disorder.
Used in Development of Anxiolytic Drugs:
1-(3-CHLORO-4-FLUOROPHENYL)PIPERAZINE DIHYDROCHLORIDE is also explored for its potential as an anxiolytic drug, suggesting that it may have applications in treating anxiety disorders and related conditions.

InChI:InChI=1/C10H12ClFN2.2ClH/c11-9-7-8(1-2-10(9)12)14-5-3-13-4-6-14;;/h1-2,7,13H,3-6H2;2*1H

Upstream product

• 367-21-5 3-chloro-4-fluorophenylamine 
• 821-48-7 bis-(2-chloroethyl)amine hydrochloride 
• 60811-21-4 1-bromo-3-chloro-4-fluorobenzene 
• 615-41-8 2-iodochlorobenzene 
• 868063-71-2 4-(2-chlorophenyl)-1,4-diazepane-1-carboxylic acid tert-butyl ester 

Downstream Products

• 91532-32-0 (chloro-3 fluoro-4 phenyl)-1 (chloro-3 propyl)-4 piperazine 
• 91532-40-0 3-{3-[4-(3-Chloro-4-fluoro-phenyl)-piperazin-1-yl]-propyl}-3H-benzo[d][1,2,3]triazin-4-one 
• 1027492-65-4 {2-amino-4-[(4-(3-chloro-4-fluorophenyl)piperazin-1-yl)methyl]thiophen-3-yl}(4-chlorophenyl)methanone 
• 1355156-04-5 2-{3-(4-chlorobenzoyl)-4-[(4-(3-chloro-4-fluorophenyl)piperazin-1-yl)methyl]thiophen-2-yl}-isoindole-1,3-dione 
• 1401688-35-4 C₂₄H₂₀ClFN₄ 

Relevant articles and documents

PYRROLE mTORC INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

4-Substituted-2-phenylquinazolines as inhibitors of BCRP

We investigated several 2-phenylquinazolines with different substitutions at position 4 for their BCRP inhibition. Compounds with phenyl ring attached via an amine-containing linker at position 4 were found to be potent inhibitors of BCRP. In general compounds with meta substitution of phenyl ring at position 4 were found to have higher inhibitory effect, compound 12 being the most potent and selective towards BCRP.

1,2,4-TRIAZOL-3-ONE ANTIDEPRESSANTS

Phenoxyalkyl substituted-1,2,4-triazolones having anti-depressant properties typified by 2-3-4-(3-chlorophenyl)-1-piperazinyl!propyl!-5-ethyl-4-(2-phenoxyethyl)-2H-1,2, 4-triazol-3(4H)-one are disclosed.