915390-61-3

Basic information

• Product Name: 1-benzyl-3-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyrrolidine
• CAS NO: 915390-61-3
• Molecular Weight: 305.536
• Mol File: 915390-61-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-benzyl-3-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-3-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyrrolidine(915390-61-3)
• EPA Substance Registry System: 1-benzyl-3-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyrrolidine(915390-61-3)

Safety Data

• Hazardous Substances Data: 915390-61-3(Hazardous Substances Data)

Upstream product

• 5731-17-9 1-(Phenylmethyl)-3-pyrrolidinemethanol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 51535-00-3 methyl 1-benzyl-5-oxo-3-pyrrolidinecarboxylate 

Relevant articles and documents

PYRROLIDINE DERIVATIVE OR SALT THEREOF

[PROBLEMS] To provide a compound which can be used for the treatment of a disease associated with a calcium-sensing receptor (CaSR), particularly hyperparathyroidism. [MEANS FOR SOLVING PROBLEMS] It is found that a novel pyrrolidine derivative having an aminomethyl group substituted by an arylaklyl group or the like or a salt thereof has an excellent CaSR agonistic modulation effect and also has an excellent selectivity in the inhibition of CYP2D6 which may cause a drug-drug interaction. Thus, the novel pyrrolidine derivative is useful as a therapeutic agent for a disease associated with CaSR (e.g., hyperparathyroidism, renal osteodystrophy and hypercalcemia).