915390-72-6

Basic information

• Product Name: (4S)-3-[(2E)-3-(3-fluorophenyl)prop-2-enoyl]-4-phenyl-1,3-oxazolidin-2-one
• Synonyms: (4S)-3-[(2E)-3-(3-fluorophenyl)prop-2-enoyl]-4-phenyl-1,3-oxazolidin-2-one
• CAS NO: 915390-72-6
• Molecular Weight: 311.312
• Mol File: 915390-72-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (4S)-3-[(2E)-3-(3-fluorophenyl)prop-2-enoyl]-4-phenyl-1,3-oxazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (4S)-3-[(2E)-3-(3-fluorophenyl)prop-2-enoyl]-4-phenyl-1,3-oxazolidin-2-one(915390-72-6)
• EPA Substance Registry System: (4S)-3-[(2E)-3-(3-fluorophenyl)prop-2-enoyl]-4-phenyl-1,3-oxazolidin-2-one(915390-72-6)

Safety Data

• Hazardous Substances Data: 915390-72-6(Hazardous Substances Data)

Upstream product

• 20595-30-6 3-fluorocinnamic acid 
• 39098-87-8 3-fluoro-cinnamoyl chloride 
• 99395-88-7 (S)-4-phenyl-2-oxazolidinone 
• 20595-30-6 3-Fluorocinnamic acid 
• 13565-05-4 (E)-3-(3-fluorophenyl)acryloyl chloride 

Relevant articles and documents

PIPERAZINE DERIVATIVES AS HIV PROTEASE INHIBITORS

The present invention is directed to piperazine derivatives, pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.

PYRROLIDINE DERIVATIVE OR SALT THEREOF

[PROBLEMS] To provide a compound which can be used for the treatment of a disease associated with a calcium-sensing receptor (CaSR), particularly hyperparathyroidism. [MEANS FOR SOLVING PROBLEMS] It is found that a novel pyrrolidine derivative having an aminomethyl group substituted by an arylaklyl group or the like or a salt thereof has an excellent CaSR agonistic modulation effect and also has an excellent selectivity in the inhibition of CYP2D6 which may cause a drug-drug interaction. Thus, the novel pyrrolidine derivative is useful as a therapeutic agent for a disease associated with CaSR (e.g., hyperparathyroidism, renal osteodystrophy and hypercalcemia).