915410-93-4

Basic information

• Product Name: Benzene, 1,3-dibromo-5-[(4-methoxyphenyl)methoxy]-
• Synonyms: 3,5-dibromo-1-p-methoxy-benzyloxybenzene
• CAS NO: 915410-93-4
• Molecular Formula: C14H12Br2O2
• Molecular Weight: 372.056
• Mol File: 915410-93-4.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 410.3±35.0 °C(Predicted)
• Density: 1.614±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Benzene, 1,3-dibromo-5-[(4-methoxyphenyl)methoxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1,3-dibromo-5-[(4-methoxyphenyl)methoxy]-(915410-93-4)
• EPA Substance Registry System: Benzene, 1,3-dibromo-5-[(4-methoxyphenyl)methoxy]-(915410-93-4)

Safety Data

• Hazardous Substances Data: 915410-93-4(Hazardous Substances Data)

Upstream product

• 626-41-5 3,5-dibromophenol 
• 2746-25-0 p-Methoxybenzyl bromide 
• 827-94-1 2,6-dibromo-4-nitroaniline 
• 626-39-1 1,3,5-trisbromobenzene 
• 105-13-5 4-Methoxybenzyl alcohol 
• 1435-51-4 1,3-dibromo-5-fluorobenzene 
• 6311-60-0 3,5-dibromonitrobenzene 

Downstream Products

• 1068604-40-9 3-bromo-5-((p-methoxybenzyl)oxy)benzaldehyde 
• 1421341-65-2 C₄₃H₄₆BrNO₇S 
• 1421341-68-5 C₃₀H₄₉BrO₄Si₂ 
• 1421341-69-6 C₃₂H₅₃NO₅Si₂ 
• 1421341-70-9 C₃₂H₅₀F₃NO₅Si₂ 
• 1421341-71-0 C₂₄H₄₅NO₄Si₂ 
• 1421341-72-1 C₂₄H₄₃NO₅Si₂ 
• 1421341-73-2 C₂₄H₄₅NO₅Si₂ 
• 1421341-66-3 C₄₉H₆₀BrNO₇SSi 
• 915411-49-3 [3-bromo-5-(4-methoxy-benzyloxy)-phenyl]-(1-oxy-pyridin-3-yl)-amine 
• 915412-24-7 [3-bromo-5-(4-methoxy-benzyloxy)-phenyl]-(6-methoxy-pyridin-3-yl)-methanone 

Relevant articles and documents

Process research on a phenoxybutyric acid LTB4 receptor antagonist. Efficient kilogram-scale synthesis of a 3,5-bisarylphenol core

An improved, kilogram-scale synthesis of a LTB4 receptor antagonist is reported. The title compound was prepared in four linear steps (seven steps total) and 54% overall yield. The 3,5-bisarylphenol core was obtained in nearly quantitative yield by the condensation of 1-benzotriazol-1-ylpropan-2-one with a chalcone. Although all the intermediates were oils, no chromatography purification was required.

Synthesis and pharmacological evaluation of N -(3-(1 H -Indol-4-yl)-5-(2- methoxyisonicotinoyl)phenyl)methanesulfonamide (LP-261), a potent antimitotic agent

The synthesis and optimization of a series of orally bioavailable 1-(1H-indol-4-yl)-3,5-disubstituted benzene analogues as antimitotic agents are described. A functionalized dibromobenzene intermediate was used as a key scaffold, which when modified by sequential Suzuki coupling and Buchwald-Hartwig amination provided a flexible entry to 1,3,5-trisubstituted phenyl compounds. A 1H-indol-4-yl moiety at the 1-position was determined to be a critical feature for optimal potency. The compounds have been shown to induce cell cycle arrest at the G2/M phase and demonstrate efficacy in both cell viability and cell proliferation assays. The primary site of action for these agents is revealed by their colchicine competitive inhibition of tubulin polymerization, and a computational model has been developed for the association of these compounds to tubulin. An optimized lead LP-261 significantly inhibits growth of a human non-small-cell lung tumor (NCI-H522) in a mouse xenograft model.

LEUKOTRIENE B4 INHIBITORS

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, COPD