91559-28-3

Basic information

• Product Name: benzyl piperazine-1-carbodithioate
• Synonyms: benzyl piperazine-1-carbodithioate
• CAS NO: 91559-28-3
• Molecular Weight: 252.404
• Mol File: 91559-28-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: benzyl piperazine-1-carbodithioate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl piperazine-1-carbodithioate(91559-28-3)
• EPA Substance Registry System: benzyl piperazine-1-carbodithioate(91559-28-3)

Safety Data

• Hazardous Substances Data: 91559-28-3(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 1605349-59-4 tert-butyl 4-(benzylthiocarbonothioyl)piperazine-1-carboxylate 
• 139160-74-0 sodium 4-(tert-butoxycarbonyl)piperazine-1-carbodithioate 
• 99-00-3 piperazine-1-carbodithioic acid 
• 100-44-7 benzyl chloride 

Downstream Products

• 1605349-68-5 sodium 4-(benzylthiocarbonothioyl)piperazine-1-carbodithioate 
• 109400-03-5 benzyl 4-benzylpiperazine-1-carbodithioate 
• 21585-27-3 dibenzyl piperazine-1,4-bis(carbodithioate) 
• 1605349-69-6 benzyl 4-allylpiperazine-1-carbodithioate 
• 1605349-74-3 1-allyl 4-benzyl piperazine-1,4-bis(carbodithioate) 
• 1605349-70-9 benzyl 4-butylpiperazine-1-carbodithioate 
• 1605349-75-4 1-benzyl 4-butyl piperazine-1,4-bis(carbodithioate) 
• 1605349-71-0 benzyl 4-(2-(piperidin-1-yl)ethyl) piperazine-1-carbodithioate 
• 1605349-76-5 1-benzyl 4-(2-( piperidin-1-yl)ethyl)piperazine-1,4-bis(carbodithioate) 
• 1621964-49-5 bis(4-benzylthiocarbonothioyl-1-piperazinylthiocarbonyl) disulfide 
• 125155-66-0 Benzyl 4-(2,3,4-trihydroxybenzyl)-1-piperazinecarbodithioate 

Relevant articles and documents

Design, synthesis and antitumor evaluation of new 1,8-naphthalimide derivatives targeting nuclear DNA

Four series of new 3-nitro naphthalimides derivatives, 4(4a?4f), 5(5a?5i), 6(6a?6e) and 7 (7a?7j), were designed and synthesized as antitumor agents. Methyl thiazolyl tetrazolium (MTT) screening assay results revealed that some compounds displayed effecti

Dithiocarbamate-thiourea hybrids useful as vaginal microbicides also show reverse transcriptase inhibition: Design, synthesis, docking and pharmacokinetic studies

Prophylactic prevention is considered as the most promising strategy to tackle STI/HIV. Twenty-five dithiocarbamate-thiourea hybrids (14-38) were synthesized as woman controlled topical vaginal microbicides to counter Trichomonas vaginalis and sperm along with RT inhibition potential. The four promising compounds (18, 26, 28 and 33) were tested for safety through cytotoxic assay against human cervical cell line (HeLa) and compatibility with vaginal flora, Lactobacillus. Docking study of most promising vaginal microbicide (33) revealed that it docked in a position and orientation similar to known reverse transcriptase inhibitor Nevirapine. The preliminary in vivo pharmacokinetics of compound 33 was performed in NZ-rabbits to evaluate systemic toxicity in comparison to Nonoxynol-9.

Therapeutic agent for liver disease and piperazine derivatives

A therapeutic agent for liver disease containing as an active ingredient a piperazine derivative having the formula: STR1 wherein, A represents a phenyl, p-benzoquinonyl or cumarinyl group which may have at least one substituent selected from the group consisting of halogen, alkyl, fluoroalkyl, formyl, alkoxycarbonyl, acyl, hydroxy, alkoxy, acyloxy, glycosyloxy, amino, alkylamino, mercapto, alkylthio and nitro; B represents a single bond or a straight chain alkylene group containing 1-4 carbon atoms which may have at least one substituent selected from the group consisting of alkyl, aryl, aralkyl, hydroxy and oxo; R represents an atom or a group selected from the group consisting of hydrogen, alkali metal, alkaline earth metal, alkyl, cycloalkyl, aralkyl and aryl; and n is 2 or 3, or its pharmaceutically acceptable salt is disclosed.