915774-28-6

Basic information

• Product Name: Benzonitrile, 4-amino-2-[(3-methyl-2-buten-1-yl)oxy]-
• CAS NO: 915774-28-6
• Molecular Formula: C12H14N2O
• Molecular Weight: 202.256
• Mol File: 915774-28-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzonitrile, 4-amino-2-[(3-methyl-2-buten-1-yl)oxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 4-amino-2-[(3-methyl-2-buten-1-yl)oxy]-(915774-28-6)
• EPA Substance Registry System: Benzonitrile, 4-amino-2-[(3-methyl-2-buten-1-yl)oxy]-(915774-28-6)

Safety Data

• Hazardous Substances Data: 915774-28-6(Hazardous Substances Data)

Downstream Products

• 933045-45-5 4-(4-chloro-6-methyl-[1,3,5]triazin-2-ylamino)-2-(3-methyl-but-2-enyloxy)-benzonitrile 
• 915774-04-8 4-(4-chloro-[1,3,5]triazin-2-ylamino)-2-(3-methyl-but-2-enyloxy)-benzonitrile 

Relevant articles and documents

Optimization of pyrimidinyl- and triazinyl-amines as non-nucleoside inhibitors of HIV-1 reverse transcriptase

Non-nucleoside inhibitors of HIV-1 reverse transcriptase are being pursued through synthesis and assaying for anti-viral activity. Following computational analyses, the focus has been on the motif Het-NH-Ph-U, where Het is an aromatic heterocycle and U is an unsaturated, hydrophobic group. Previous investigations with Het = 2-thiazoyl and 2-pyrimidinyl are extended here to triazinyl derivatives. The result is several NNRTIs in the 2-20 nM range with negligible cytotoxicity and auspicious predicted pharmacological properties.