91591-70-7

Basic information

• Product Name: 2,6-Dichloro-4-methylpyridine-3-carboxaldehyde
• Synonyms: 2,6-Dichloro-4-methylpyridine-3-carboxaldehyde;2,6-Dichloro-4-Methylnicotinaldehyde;2,6-dichloro-4-methylpyridine-3-carbaldehyde
• CAS NO: 91591-70-7
• Molecular Formula: C7H5Cl2NO
• Molecular Weight: 190.03
• Mol File: 91591-70-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2,6-Dichloro-4-methylpyridine-3-carboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Dichloro-4-methylpyridine-3-carboxaldehyde(91591-70-7)
• EPA Substance Registry System: 2,6-Dichloro-4-methylpyridine-3-carboxaldehyde(91591-70-7)

Safety Data

• Hazardous Substances Data: 91591-70-7(Hazardous Substances Data)

Usage

General Description

2,6-Dichloro-4-methylpyridine-3-carboxaldehyde is a chemical compound with a molecular formula C7H5Cl2NO. It is a yellow-to-brown liquid that is used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. This chemical is commonly used as a building block in the production of various drugs and pesticides. It is known for its strong odor and is classified as a hazardous substance, requiring careful handling and storage. 2,6-Dichloro-4-methylpyridine-3-carboxaldehyde is also used as a reagent in organic chemistry reactions, and its structure and properties make it a valuable tool in chemical synthesis.

Upstream product

• 875-35-4 2,6-dichloro-4-methylnicotinonitrile 
• 1086322-08-8 (2,6-dichloro-4-methylpyridin-3-yl)methanol 
• 62774-90-7 2,6-dichloro-4-methyl-nicotinic acid 

Downstream Products

• 62774-90-7 2,6-dichloro-4-methyl-nicotinic acid 
• 220559-34-2 methyl 4.6-dichloro-3-(diethylamino)furo[3,4-c]pyridine-1-carboxylate 

Relevant articles and documents

CYCLIC COMPOUNDS AND METHODS OF USING SAME

The present application relates to compounds of Formula (I), as defined herein, and pharmaceutically acceptable salts thereof which are MALT1 inhibitors. The present application also describes pharmaceutical composition comprising a compound of Formula (I), and pharmaceutically acceptable salts thereof, and methods of using the compounds and compositions for treating diseases, such as cancer, autoimmune disorders, and inflammatory disorders.

Synthesis and Reactions of a Stable o-Quinoid 10-π-Electron System, Furo[3,4-c]pyridine

Methyl 4,6-dichloro-3-(diethylamino)furo[3,4-c]pyridine-1-carboxylate (6), an intermediate in the Hamaguchi-Ibata reaction involving the RhII-catalyzed intramolecular reaction of a diazo group with the carbonyl of an adjacent amido group, has been isolated and characterized. PM3 calculations reveal the heat of formation (ΔHf) of this remarkably stable molecule to be -77.7 kcal/mol. Compound 6 undergoes a facile Diels-Alder cycloaddition with a variety of dienophiles to give polysubstituted isoquinoline derivatives via ring opening of initially formed cycloadducts. In each case the cycloaddition proceeds with high regioselectivity, with the electron-withdrawing group located ortho to the amino group. The most favorable FMO interaction is between the HOMO of the azaisobenzofuran 6 and the LUMO of the dienophile. The atomic coefficient at the ester carbon of the azaisobenzofuran 6 is larger than the amino center, and this nicely accommodates the observed regioselectivity.