915920-46-6Relevant articles and documents
Design, synthesis and biological evaluation of 2-styryl-5-hydroxy-4-pyrone derivatives and analogues as multiple functional agents with the potential for the treatment of Alzheimer's disease
Hu, Chenxian,Jiang, Liu,Tang, Li,Zhang, Minkui,Sheng, Rong
, (2021/07/19)
A novel series of 2-styryl-5-hydroxy-4-pyrone derivatives and analogues were designed and synthesized as H3 receptor antagonism based multitarget-directed ligands (MTDLs) for AD therapy using pharmacophore-combine strategy. The 2-styryl-5-hydro
Identification of 2-arylbenzimidazoles as potent human histamine H4 receptor ligands
Lee-Dutra, Alice,Arienti, Kristen L.,Buzard, Daniel J.,Hack, Michael D.,Khatuya, Haripada,Desai, Pragnya J.,Nguyen, Steven,Thurmond, Robin L.,Karlsson, Lars,Edwards, James P.,Breitenbucher, J. Guy
, p. 6043 - 6048 (2007/10/03)
A series of 2-arylbenzimidazoles was synthesized and found to bind with high affinity to the human histamine H4 receptor. Structure-activity relationships were investigated through library preparation and evaluation as well as traditional medicinal chemistry approaches, leading to the discovery of compounds with single-digit nanomolar affinity for the H4 receptor.