916069-80-2

Basic information

• Product Name: (S)-4-(FLUOROMETHYL)-DIHYDROFURAN-2(3H)-ONE
• Synonyms: (S)-4-(FLUOROMETHYL)-DIHYDROFURAN-2(3H)-ONE;2(3H)-Furanone, 4-(fluoroMethyl)dihydro-,;(4S)-4-(Fluoromethyl)dihydro-2(3H)-furanone;(-)-(S)-4-(Fluoromethyl)dihydrofuran-2-one
• CAS NO: 916069-80-2
• Molecular Formula: C5H7FO2
• Molecular Weight: 118.106
• Mol File: 916069-80-2.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (S)-4-(FLUOROMETHYL)-DIHYDROFURAN-2(3H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-4-(FLUOROMETHYL)-DIHYDROFURAN-2(3H)-ONE(916069-80-2)
• EPA Substance Registry System: (S)-4-(FLUOROMETHYL)-DIHYDROFURAN-2(3H)-ONE(916069-80-2)

Safety Data

• Hazardous Substances Data: 916069-80-2(Hazardous Substances Data)

Usage

Description

(S)-4-(Fluoromethyl)-dihydrofuran-2(3H)-one, with the molecular formula C5H7FO2, is a heterocyclic compound characterized by a furan ring with a fluoromethyl substituent. This unique structure and its properties render it a valuable building block in the fields of organic synthesis and pharmaceutical research. It is essential to exercise caution when handling this compound due to its potential health and environmental hazards.

Uses

Used in Organic Synthesis:
(S)-4-(Fluoromethyl)-dihydrofuran-2(3H)-one is used as a key intermediate in organic synthesis for the preparation of various organic compounds. Its distinctive structure allows for the creation of a wide range of molecules with diverse applications.
Used in Pharmaceutical Research:
In the pharmaceutical industry, (S)-4-(Fluoromethyl)-dihydrofuran-2(3H)-one serves as a crucial building block for the development of new drugs. Its unique properties make it an attractive candidate for the design and synthesis of novel therapeutic agents.

Upstream product

• 916069-77-7 4-fluoromethyl-5H-furan-2-one 
• 1021943-70-3 C₁₂H₂₁FO₅ 
• 85701-08-2 (R)-4-(hydroxymethyl)dihydrofuran-2(3H)-one 
• 916069-73-3 3-tert-butoxymethyl-4-fluoro-3-hydroxybutyric acid tert-butyl ester 
• 916069-74-4 4-fluoromethyl-4-hydroxy-dihydro-furan-2-one 
• 1333377-20-0 C₁₃H₂₅FO₃ 
• 1333379-12-6 C₇H₉ClO₄ 
• 1333379-20-6 C₅H₇ClO₂ 
• 1333378-95-2 C₉H₁₆O₄ 
• 80904-75-2 4-hydroxymethyl-5H-furan-2-one 
• 127181-22-0 (1R,5S)-methyl 2-oxo-3-oxabicyclo[3.1.0]hexane-1-carboxylate 
• 201804-32-2 tert-butyl 4-hydroxy-3-(hydroxymethyl)butanoate 
• 192214-01-0 Toluene-4-sulfonic acid (S)-5-oxo-tetrahydro-furan-3-ylmethyl ester 

Relevant articles and documents

Development of a scalable synthesis of (S)-3-fluoromethyl-γ- butyrolactone, building block for Carmegliptin's Lactam moiety

Several new routes are reported for the synthesis of (S)-3-fluoromethyl- γ-butyrolactone. An asymmetric hydrogenation-based synthesis was chosen as the enabling route to produce the lactone on a 10-kg scale. A superior stereoselective route starting from (S)-tert-butyl glycidyl ether which afforded the desired lactone in three steps with ～50% overall yield was finally selected for further development and production.

PROCESS FOR THE PREPARATION OF (S)-4-FLUOROMETHYL-DIHYDRO-FURAN-2-ONE

The present invention relates to a process of the preparation of (S)-4-fluoromethyl-dihydro-furan-2-one of the formula by employing a dialkylmalonate of the formula wherein R1b is lower alkyl, and the use of this process for the manufacture of DPP-IV inhibitors that are useful for the treatment and/or prophylaxis of diseases such as diabetes.

PROCESS FOR THE PREPARATION OF PYRIDO [ 2-1-A] ISOQUINOLINE DERIVATIVES BY CATALYTIC ASYMMETRIC HYDROGENATION OF AN ENAMINE

The invention relates to a process for the preparation of pyrido[2,1-a] isoquinoline derivatives of the formula wherein R2, R3and R4 are as defined in the specification, comprising the steps of a) catalytic asymmetric hydr