916420-28-5

Basic information

• Product Name: 2H-Pyrazol-3-ylamine
• Synonyms: 2H-Pyrazole-3-ylamine;1H-Pyrazol-5-amine 95+%
• CAS NO: 916420-28-5
• Molecular Formula: C3H5N3
• Molecular Weight: 0
• EINECS: 217-338-1
• Product Categories: Pyrazole series;Amines;Pyrazoles & Triazoles;Pyrazoles & Triazoles
• Mol File: 916420-28-5.mol
• Article Data: 9

Chemical Properties

• Melting Point: 33-39℃
• Boiling Point: 288.454°C at 760 mmHg
• Flash Point: 182.569°C
• Appearance: /
• Density: 1.313g/cm³
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.648
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 2H-Pyrazol-3-ylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Pyrazol-3-ylamine(916420-28-5)
• EPA Substance Registry System: 2H-Pyrazol-3-ylamine(916420-28-5)

Safety Data

• Hazard Codes: C:Corrosive;;
• Statements: R22:; R34:; R36/37/38:
• Safety Statements: S26:; S36/37/39:; S45:
• Hazardous Substances Data: 916420-28-5(Hazardous Substances Data)

Usage

General Description

2H-Pyrazol-3-ylamine is a chemical compound with the molecular formula C3H5N3. It is also known as 3-Aminopyrazole and is a heterocyclic amine. It is commonly used as a building block in organic synthesis and in the pharmaceutical industry for the preparation of various drugs and drug candidates. Its structure contains a pyrazole ring with an amino group attached to the third carbon, making it a versatile intermediate for the synthesis of various biologically active compounds. 2H-Pyrazol-3-ylamine is also used in the synthesis of agrochemicals, dyes, and other chemicals. It is a white to light yellow solid that is stable under normal conditions and is relatively non-toxic.

InChI:InChI=1/C3H5N3/c4-3-1-2-5-6-3/h1-2H,(H3,4,5,6)

Upstream product

• 41680-34-6 3-aminopyrazole-4-carboxylic acid 
• 871-29-4 trans-β-chloroacrylonitrile 
• 26621-44-3 3-nitro-1H-pyrazole 
• 6162-76-1 cyanoacetaldehyde 

Downstream Products

• 99898-82-5 5-(p-nitrophenyl)pyrazolo<1,5-a>pyrimidin-7-one 
• 99898-81-4 5-(p-chlorophenyl)pyrazolo<1,5-a>pyrimidin-7-one 
• 109013-09-4 3-Phenyl-pyrazolo<5,1-d>-1,2,3,5-tetrazin-4(3H)-on 
• 134242-03-8 2,2-Dimethyl-4-phenoxy-2,3-dihydro-pyrazolo<1,5-a>-s-triazin 
• 134242-04-9 2,2-Dimethyl-p-tolyl-oxy-2,3-dihydro-pyrazolo<1,5-a>-s-triazin 
• 127631-99-6 1-benzoyl-1-phenyl-N-<3(5)-pyrazolyl>methanimine 
• 266993-91-3 N,N-dimethyl-N-(1H-pyrazol-3-yl)-formamidine 

Relevant articles and documents

Synthesis of aminopyrazole analogs and their evaluation as CDK inhibitors for cancer therapy

We synthesized a library of aminopyrazole analogs to systematically explore the hydrophobic pocket adjacent to the hinge region and the solvent exposed region of cyclin dependent kinases. Structure-activity relationship studies identified an optimal substitution for the hydrophobic pocket and analog 24 as a potent and selective CDK2/5 inhibitor.

Rapid reduction of heteroaromatic nitro groups using catalytic transfer hydrogenation with microwave heating

A method for the rapid, safe reduction of heteroaromatic and aromatic nitro groups to amines is described using catalytic transfer hydrogenation under microwave heating conditions. Commonly available Pd/C or Pt/C catalyst is extremely effective with 1,4-cyclohexadiene as the hydrogen transfer source. In the case of substrates containing potentially labile aromatic halogens, Pt/C is effective and results in little or no dehalogenation. In general, the reactions are complete within 5 min at 120 °C.

Methods of treating cytokine mediated diseases

Disclosed are methods of treating certain cytokine mediated diseases or conditions using novel aromatic heterocyclic compounds of the formula(I) wherein Ar1,Ar2,L,Q and X are described herein.