916482-37-6

Basic information

• Product Name: C₂₂H₃₀ClN₃O₂S
• CAS NO: 916482-37-6
• Molecular Weight: 436.018
• Mol File: 916482-37-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₂₂H₃₀ClN₃O₂S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₃₀ClN₃O₂S(916482-37-6)
• EPA Substance Registry System: C₂₂H₃₀ClN₃O₂S(916482-37-6)

Safety Data

• Hazardous Substances Data: 916482-37-6(Hazardous Substances Data)

Upstream product

• 916482-29-6 ethyl 2-[(4,6-dichloropyrimidin-2-yl)sulfanyl]octanoate 
• 87-59-2 2,3-Dimethylaniline 

Downstream Products

• 916482-17-2 2-[4-chloro-6-(2,3-dimethyl-phenylamino)-pyrimidin-2-ylsulfanyl]-octanoic acid 

Relevant articles and documents

Rational design of a pirinixic acid derivative that acts as subtype-selective PPARγ modulator

Peroxisome proliferator-activated receptor γ (PPARγ) is involved in glucose and lipid homeostasis. PPARγ agonists are in clinical use for the treatment of type 2 diabetes. Lately, a new class of selective PPARγ modulators (SPPARγMs) was developed, which are believed to show less side effects than full PPARγ agonists. We have previously shown that α-substitution of pirinixic acid, a moderate agonist of PPARα and PPARγ, leads to low micromolar active balanced dual agonists of PPARα and PPARγ. Herein we present modifications of pirinixic acid leading to subtype-selective PPARγ agonists and furthermore the development of a selective PPARγ modulator guided by molecular docking studies.