916484-09-8

Basic information

• Product Name: 1-(4-methoxy-benzenesulfonyl)-2,3-dihydro-1H-indol-7-ylamine
• Synonyms: 1-(4-methoxy-benzenesulfonyl)-2,3-dihydro-1H-indol-7-ylamine
• CAS NO: 916484-09-8
• Molecular Weight: 304.37
• Mol File: 916484-09-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-(4-methoxy-benzenesulfonyl)-2,3-dihydro-1H-indol-7-ylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methoxy-benzenesulfonyl)-2,3-dihydro-1H-indol-7-ylamine(916484-09-8)
• EPA Substance Registry System: 1-(4-methoxy-benzenesulfonyl)-2,3-dihydro-1H-indol-7-ylamine(916484-09-8)

Safety Data

• Hazardous Substances Data: 916484-09-8(Hazardous Substances Data)

Upstream product

• 98-68-0 4-methoxy-phenyl-sulphonyl chloride 
• 80166-90-1 5-Bromo-7-nitroindoline 
• 916484-30-5 5-bromo-1-(4-methoxy-benzenesulfonyl)-2,3-dihydro-1H-indol-7-ylamine 

Downstream Products

• 916484-16-7 N-[1-(4-methoxy-benzenesulfonyl)-2,3-dihydro-1H-indol-7-yl]-4-isonicotinamide 

Relevant articles and documents

1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase

We report structure-activity relationships of 1-arylsulfonyl indoline based benzamides. The benzamide (9) exhibits striking tubulin inhibition with an IC50 value of 1.1 μM, better than that of combretastain A-4 (3), and substantial antiproliferative activity against a variety of cancer cells, including MDR-positive cell lines with an IC50 value of 49 nM (KB), 79 nM (A549), 63 nM (MKN45), 64 nM (KB-VIN10), 43 nM (KB-S15), and 46 nM (KB-7D). Dual inhibitory potential of compound 9 was found as it demonstrated significant inhibitory potential against HDAC1, 2 and 6 in comparison to MS-275 (6). Some key interactions of 9 with the amino acid residues of the active site of tubulin and with amino acid residues of HDAC 1 isoform have been figured out by molecular modeling. Compound 9 also demonstrated significant in vivo efficacy in the human non-small cell lung cancer A549 xenograft model as well as B-cell lymphoma BJAB xenograft tumor model.

Indoline-sulfonamides compounds

A series of indoline-sulfonamide compounds is disclosed. The formula of indoline-sulfonamide compounds is shown as formula (I). In formula (I), R1 is H or halogen; R2 is Ar, Ar—C(O)—, Ar—CH2—, Ar—SO2—, Ar—O—C(O)

7-Aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents

A novel series of 7-aroyl-aminoindoline-1-benzenesulfonamides showed excellent activity as inhibitors of tubulin polymerization through binding with the colchicine binding site of microtubules. Compound 15 and 16 display IC 50 values of 1.1 and