91658-92-3

Basic information

• Product Name: 2-FLUORO-3-HYDROXYBENZOIC ACID
• Synonyms: 2-FLUORO-3-HYDROXYBENZOIC ACID;3-Carboxy-2-fluorophenol;2-Fluoro-3-(hydoxyMethyl)benzoic acid;2-Fluoro-3-carboxyphenol
• CAS NO: 91658-92-3
• Molecular Formula: C₇H₅FO₃
• Molecular Weight: 156.11
• Product Categories: pharmacetical;Benzoic acid
• Mol File: 91658-92-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 314.1°C at 760 mmHg
• Flash Point: 143.8°C
• Appearance: /
• Density: 1.492g/cm³
• Vapor Pressure: 0.000202mmHg at 25°C
• Refractive Index: 1.585
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-FLUORO-3-HYDROXYBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-3-HYDROXYBENZOIC ACID(91658-92-3)
• EPA Substance Registry System: 2-FLUORO-3-HYDROXYBENZOIC ACID(91658-92-3)

Safety Data

• Hazard Codes: C,Xi,Xn
• HazardClass: IRRITANT
• Hazardous Substances Data: 91658-92-3(Hazardous Substances Data)

Usage

General Description

2-FLUORO-3-HYDROXYBENZOIC ACID is a compound with the molecular formula C7H5FO3. It is a derivative of benzoic acid, with a fluorine atom and a hydroxyl group attached to the benzene ring. This chemical is commonly used in the production of pharmaceuticals, agrochemicals, and dyes. It can also be used as a building block in organic synthesis, due to its reactivity and ability to undergo various chemical reactions. Additionally, 2-FLUORO-3-HYDROXYBENZOIC ACID is a white crystalline solid at room temperature and is soluble in organic solvents such as ethanol and acetone.

InChI:InChI=1/C7H5FO3/c8-6-4(7(10)11)2-1-3-5(6)9/h1-3,9H,(H,10,11)

Upstream product

• 367-12-4 2-fluorophenol 
• 117570-31-7 fluoro-1 methoxymethylenoxy-2 benzene 
• 137654-20-7 2-fluoro-3-methoxybenzoic acid 

Downstream Products

• 1261621-20-8 C₇H₄ClFO₂ 
• 1214324-64-7 methyl 2-fluoro-3-hydroxybenzoate 

Relevant articles and documents

PYRROLOPYRIMIDINE ITK INHIBITORS FOR TREATING INFLAMMATION AND CANCER

Disclosed herein are arylpyridinone compounds and compositions useful in the treatment of ITK mediated diseases, such as inflammation, having the structure of Formula (I): wherein R1, R2, and X are as defined in the detailed description. Methods of inhibition of ITK activity in a human or animal subject are also provided.

Fluorophenols and (trifluoromethyl)phenols as substrates of site-selective metalation reactions: To protect or not to protect

O-Methoxymethyl (MOM) protected fluorophenols can be cleanly metalated and subsequently be submitted to site-selective electrophilic substitution. The 2- and 4-isomers exhibit ambivalent reactivity: deprotonation occurs at the position adjacent to the oxygen when butyllithium is employed whereas the position adjacent to the fluorine is attacked by the superbasic mixture of butyllithium and potassium tert-butoxide (LIC-KOR). The MOM-protected (trifluoromethyl)-phenols react exclusively at oxygen-neighboring positions. The meta isomer provides another example of optional site selectivity, undergoing hydrogen/metal exchange at the 2-position with the LIC-KOR reagent and at the 6-position with sec-butyllithium. Unprotected (trifluoromethyl)phenols can also be ortho-metalated after O-deprotonation, although the products are formed in only moderate yields.