916795-99-8Relevant articles and documents
Structure-activity relationships for a novel series of thiazolyl phenyl ether derivatives exhibiting potent and selective acetyl-CoA carboxylase 2 inhibitory activity
Clark, Richard F.,Zhang, Tianyuan,Xin, Zhili,Liu, Gang,Wang, Ying,Hansen, T. Matthew,Wang, Xiaojun,Wang, Rongqi,Zhang, Xiaolin,Frevert, Ernst U.,Camp, Heidi S.,Beutel, Bruce A.,Sham, Hing L.,Gu, Yu Gui
, p. 6078 - 6081 (2007/10/03)
Structure-activity relationships for a recently discovered thiazolyl phenyl ether series of acetyl-CoA carboxylase (ACC) inhibitors were investigated. Preliminary efforts to optimize the series through modification of the distal aryl ether moiety of the l