916904-25-1

Basic information

• Product Name: tert-butyl 2-bromo-5-chlorobenzoate
• CAS NO: 916904-25-1
• Molecular Weight: 291.572
• Mol File: 916904-25-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl 2-bromo-5-chlorobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 2-bromo-5-chlorobenzoate(916904-25-1)
• EPA Substance Registry System: tert-butyl 2-bromo-5-chlorobenzoate(916904-25-1)

Safety Data

• Hazardous Substances Data: 916904-25-1(Hazardous Substances Data)

Upstream product

• 21739-93-5 2-bromo-5-chlorobenzoic acid 
• 75-65-0 tert-butyl alcohol 

Relevant articles and documents

Potent and selective TF/FVIIa inhibitors containing a neutral P1 ligand

Inhibition of tissue factor/factor VIIa complex (TF/FVIIa) is an attractive strategy for antithrombotic therapies. We began with an investigation of a non-amidine TF/FVIIa inhibitor based on a modification of amidine compound 1. Optimization of the substituents on the P1 phenyl portion of the compound 1 led to a neutral or less basic alternative for the 4-amidinophenyl moiety. By further optimization of the substituents on the central phenyl ring, a highly potent and selective TF/FVIIa inhibitor 17d was discovered.