91751-59-6

Basic information

• Product Name: (4-chlorophenyl)[2-(2-hydroxy-5-methylphenyl)-3,3-dimethylindolin-1-yl]methanone
• CAS NO: 91751-59-6
• Molecular Weight: 391.897
• Mol File: 91751-59-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (4-chlorophenyl)[2-(2-hydroxy-5-methylphenyl)-3,3-dimethylindolin-1-yl]methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (4-chlorophenyl)[2-(2-hydroxy-5-methylphenyl)-3,3-dimethylindolin-1-yl]methanone(91751-59-6)
• EPA Substance Registry System: (4-chlorophenyl)[2-(2-hydroxy-5-methylphenyl)-3,3-dimethylindolin-1-yl]methanone(91751-59-6)

Safety Data

• Hazardous Substances Data: 91751-59-6(Hazardous Substances Data)

Upstream product

• 106-44-5 p-cresol 
• 51459-50-8 (4-chlorophenyl)(2-hydroxy-3,3-dimethyl-2,3-dihydroindol-1-yl)methanone 

Relevant articles and documents

Role of 2-naphthyl ether intermediate in formation of isolable atropisomers derived from the coupling reaction of (2-hydroxy-3,3-dimethylindolin-l-yl)-(substituted phenyl)methanones with 2-naphthol

The formation pathway of the atropisomers derived from the reaction of (2-hydroxy-3,3-dimethylindolin-l-yl)(4-substituted phenyl)methanones with 2-naphthol in the presence of BF3·Et2O was discussed on the basis of the isolation of the 2-naphthyl ether intermediate whose structure was determined by single crystal X-ray analysis. The results indicate that the coupling reaction proceeds through stepwise mechanism, i.e., the ether intermediate formation followed by Fries-type rearrangement.

A CONVENIENT SYNTHETIC METHOD OF 1-ACYL-2-ARYL-3,3-DIMETHYLINDOLINE INVOLVING ISOLABLE DIASTEREOMERIC ATROPISOMERS

The synthesis of 1-acyl-2-aryl-3,3-dimethylindoline was improved by the reaction of 1-acyl-2-hydroxy-3,3-dimethylindoline with an arene in the presence of BF3*O(C2H5)2 in dioxane, and stable diastereomeric atropisomers were isolated as products when the a