91759-67-0

Basic information

• Product Name: Benzoic acid, 3,4-dimethoxy-, 2-[(phenylamino)thioxomethyl]hydrazide
• CAS NO: 91759-67-0
• Molecular Formula: C16H17N3O3S
• Molecular Weight: 331.395
• Mol File: 91759-67-0.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 3,4-dimethoxy-, 2-[(phenylamino)thioxomethyl]hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 3,4-dimethoxy-, 2-[(phenylamino)thioxomethyl]hydrazide(91759-67-0)
• EPA Substance Registry System: Benzoic acid, 3,4-dimethoxy-, 2-[(phenylamino)thioxomethyl]hydrazide(91759-67-0)

Safety Data

• Hazardous Substances Data: 91759-67-0(Hazardous Substances Data)

Upstream product

• 93-07-2 Veratric acid 
• 3943-77-9 ethyl veratrate 
• 41764-74-3 3,4-dimethoxybenzohydrazide 
• 103-72-0 phenyl isothiocyanate 

Downstream Products

• 482654-73-9 2-[5-(3,4-dimethoxyphenyl)-4-phenyl-4H-[1,2,4]triazol-3-ylsulfanyl]-1-phenylethanone 
• 91759-72-7 ethyl 2-(5-(3,4-dimethoxyphenyl)-4-phenyl-4H-1,2,4-triazol-3-ylthio)acetate 
• 91759-73-8 2-(5-(3,4-dimethoxyphenyl)-4-phenyl-4H-1,2,4-triazol-3-ylthio)acetic acid 
• 91759-75-0 [5-(3,4-Dihydroxy-phenyl)-4-phenyl-4H-[1,2,4]triazol-3-ylsulfanyl]-acetic acid 
• 91759-69-2 3-(3,4-dimethoxyphenyl)-4-phenyl-4,5-dihydro-1H-1,2,4-triazole-5-thione 
• 91759-69-2 5-(3,4-dimethoxybenzyl)-4-phenyl-4H-1,2,4-triazole-3-thiol 

Relevant articles and documents

A KHSO4 mediated facile synthesis of 2-amino-1,3,4-oxadiazole derivatives

A novel, efficient and mild KHSO4 mediated synthesis for 2-amino-1,3,4-oxadiazoles has been established via the cyclodesulfurization of benzoylhydrazine and isothiocyanate derivatives in one pot. The reactions proceeded smoothly at room tempera

New 1,2,4-triazole-Chalcone hybrids induce Caspase-3 dependent apoptosis in A549 human lung adenocarcinoma cells

A series of novel 1, 2, 4-triazole/chalcone hybrids was prepared and identified with different spectroscopic techniques. The prepared compounds showed remarkable cytotoxic activity against different cancer cell lines. Compounds 24, 25, 27, 41 and 47 had shown the highest cytotoxicity among the tested compounds against human lung adenocarcinoma A549 cells with IC50 ranging from 4.4 to 16.04 μM compared to cisplatin with IC50 of 15.3 μM. Flow cytometric analysis of the tested compounds showed an increase in the number of apoptotic cells in a dose-dependent manner. The further mechanistic study demonstrated that 1, 2, 4-triazole-chalcone hybrids induced apoptosis via increased level of proapoptotic protein Bax, release of cytochrome c from mitochondria and activation of caspase-3/8/9 proteins. However, general caspase inhibition by the pan-caspase inhibitor, z-VAD-fmk, significantly decreased the apoptosis induced by the tested hybrids, suggesting dependency of apoptosis on activation of the caspase-3 pathway.

1,2,4-Triazole/oxime hybrids as new strategy for nitric oxide donors: Synthesis, anti-inflammatory, ulceroginicity and antiproliferative activities

A series of novel nitric oxide (NO) donating triazole/oxime hybrids was prepared and evaluated for their anti-inflammatory activity and antiproliferative activity. Most of the tested compounds showed significant anti-inflammatory activity using carrageenan-induced rat paw edema method compared to indomethacin. Calculation of the ulcer indices and histopathological investigation indicated that the prepared NO-donating oximes exhibited less ulcerogenicity compared to their ketone intermediates and indomethacin. The NO-donating oximes 7i and 7k achieved remarkable cell growth inhibition activity against most of the tested cell lines. Compound 7k was found to be with high selectivity against CNS subpanel with selectivity ratio of 11.99 at GI 50 level.