917878-65-0

Basic information

• Product Name: 7-BROMO-3-CHLORO-5H-BENZO[4,5]CYCLOHEPTA[1,2-B]PYRIDIN-5-ONE
• Synonyms: 7-BROMO-3-CHLORO-5H-BENZO[4,5]CYCLOHEPTA[1,2-B]PYRIDIN-5-ONE
• CAS NO: 917878-65-0
• Molecular Formula: C₁₄H₇BrClNO
• Molecular Weight: 320.58
• Mol File: 917878-65-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 459.9°C at 760 mmHg
• Flash Point: 231.9°C
• Appearance: /
• Density: 1.644g/cm³
• Vapor Pressure: 1.22E-08mmHg at 25°C
• Refractive Index: 1.677
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 7-BROMO-3-CHLORO-5H-BENZO[4,5]CYCLOHEPTA[1,2-B]PYRIDIN-5-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-BROMO-3-CHLORO-5H-BENZO[4,5]CYCLOHEPTA[1,2-B]PYRIDIN-5-ONE(917878-65-0)
• EPA Substance Registry System: 7-BROMO-3-CHLORO-5H-BENZO[4,5]CYCLOHEPTA[1,2-B]PYRIDIN-5-ONE(917878-65-0)

Safety Data

• Hazardous Substances Data: 917878-65-0(Hazardous Substances Data)

Usage

General Description

7-BROMO-3-CHLORO-5H-BENZO[4,5]CYCLOHEPTA[1,2-B]PYRIDIN-5-ONE is a chemical compound with a complex ring structure containing bromine, chlorine, and oxygen atoms. It is commonly used as a building block in the synthesis of pharmaceutical compounds and other organic materials. 7-BROMO-3-CHLORO-5H-BENZO[4,5]CYCLOHEPTA[1,2-B]PYRIDIN-5-ONE has been studied for its potential pharmacological properties, particularly in the field of medicinal chemistry. The unique structure of 7-BROMO-3-CHLORO-5H-BENZO[4,5]CYCLOHEPTA[1,2-B]PYRIDIN-5-ONE offers opportunities for the development of new drugs and materials with specific biological and chemical properties. However, it is important to handle this compound with care and follow safety guidelines due to its potential hazards.

InChI:InChI=1/C14H7BrClNO/c15-9-3-1-8-2-4-13-12(6-10(16)7-17-13)14(18)11(8)5-9/h1-7H

Upstream product

• 917882-51-0 2-[(E/Z)-2-(4-bromophenyl)vinyl]-3-carboxy-5-chloropyridinium chloride 
• 1170702-73-4 2-[(E)-2-(4-bromophenyl)vinyl]-5-chloronicotinic acid 
• 350597-49-8 2-methyl-5-chloro methylnicotinate 
• 917942-73-5 C₁₄H₉BrClNO₂ 
• 1122-91-4 4-bromo-benzaldehyde 

Downstream Products

• 917882-66-7 MK-2461 
• 1309960-89-1 N-(3-chloro-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl)-N-(2,4-dimethoxybenzyl)ethenesulfonamide 
• 1309960-90-4 N-(3-chloro-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl)-N-(2,4-dimethoxybenzyl)-2-(1H-imidazol-1-yl)ethanesulfonamide 
• 1309960-77-7 N-methyl-N'-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-(pyrazin-2-ylmethyl)sulfuric diamide 
• 917882-66-7 N-((2R)-1,4-dioxan-2-ylmethyl)-N-methyl-N’-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]sulfamide 
• 917878-68-3 3-chloro-7-[(2,4-dimethoxybenzyl)amino]-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one 
• 1427584-37-9 C₂₇H₂₂N₄O₂ 
• 1427584-36-8 C₂₆H₂₀N₄O₂ 
• 1427584-55-1 3-chloro-7-(hydroxymethyl)-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one 
• 1001915-86-1 1-(3-chloro-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl)-N-methyl-N-phenylmethanesulfonamide 
• 1001915-85-0 methyl (3-chloro-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]-pyridin-7-yl)[methyl(phenyl)sulfamoyl]acetate 

Relevant articles and documents

Process development and large-scale synthesis of a c-Met kinase inhibitor

A highly convergent synthesis of c-Met kinase inhibitor 1 has been demonstrated on a multikilogram scale using three key fragments: dihalotricyclic core 2, chiral sulfamide side chain 3, and pyrazole boronic ester 4. The chirality in sulfamide side chain 3 was installed using the cheap and readily available starting material (S)-epichlorohydrin. A total of 2.71 kg of 1 were isolated in seven steps (the longest linear sequence).

Tyrosine kinase inhibitors

This invention relates to salt forms of the compound N-[(2R)-1,4-dioxan-2-ylmethyl]-N-methyl-N′-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]sulfamide, an inhibitor of tyrosine kinases, in particular the receptor tyrosine

TYROSINE KINASE INHIBITORS

The present invention relates to pyrido[3,2-c]benzazocinone derivatives and related compounds, that are useful for treating cellular proliferative diseases, for treating disorders associated with MET activity, and for inhibiting the receptor tyrosine kina