917988-91-1

Basic information

• Product Name: Oxazole, 2-(1,1-dimethylethyl)-4,5-diphenyl-
• CAS NO: 917988-91-1
• Molecular Formula: C19H19NO
• Molecular Weight: 277.366
• Mol File: 917988-91-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Oxazole, 2-(1,1-dimethylethyl)-4,5-diphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Oxazole, 2-(1,1-dimethylethyl)-4,5-diphenyl-(917988-91-1)
• EPA Substance Registry System: Oxazole, 2-(1,1-dimethylethyl)-4,5-diphenyl-(917988-91-1)

Safety Data

• Hazardous Substances Data: 917988-91-1(Hazardous Substances Data)

Upstream product

• 630-18-2 tert-butyl isocyanide 
• 1494-20-8 2,2-difluoro-1,2-diphenylethan-1-ol 
• 754-10-9 2,2-dimethylpropionamide 
• 16483-98-0 2,3-diphenyl-2H-azirine 
• 51891-90-8 2-oxo-1,2-diphenylethyl pivalate 
• 365-01-5 2,2-difluoro-2-phenylacetophenone 
• 591-50-4 iodobenzene 
• 591-51-5 phenyllithium 
• 2248-46-6 ethyl 2,2-difluoro-2-phenylacetate 
• 3282-30-2 pivaloyl chloride 

Downstream Products

• 89549-37-1 N-pivaloyl benzamide 

Relevant articles and documents

Iron-Catalyzed Cycloaddition of Amides and 2,3-Diaryl-2 H-azirines to Access Oxazoles via C-N Bond Cleavage

A novel and efficient iron-catalyzed cycloaddition reaction using readily available 2,3-diaryl-2H-azirines and primary amides is reported. A wide range of trisubstituted oxazoles could be achieved in good yields with good functional group compatibility. In this transformation, two C-N bonds were cleaed and new C-N and C-O bonds were formed.

A Divergent Approach to Indoles and Oxazoles from Enamides by Directing-Group-Controlled Cu-Catalyzed Intramolecular C-H Amination and Alkoxylation

A directing-group-controlled, copper-catalyzed divergent approach to indoles and oxazoles from enamides has been developed. The picolinamide-derived enamides undergo the intramolecular aromatic C-H amination in the presence of a Cu(OPiv)2 catalyst and an MnO2 oxidant to form the corresponding indoles in good yields. On the other hand, simpler aryl- or alkyl-substituted enamides are converted to the 2,4,5-trisubstituted oxazole frameworks via vinylic C-H alkoxylation under identical conditions. The copper catalysis can provide uniquely divergent access to indole and oxazole heteroaromatic cores of great importance in medicinal and material chemistry.

Ceric ammonium nitrate promoted oxidation of oxazoles

The ceric ammonium nitrate promoted oxidations of 4,5-diphenyloxazoles and oxazoles with various substitution patterns have been investigated. This transformation results in the formation of the corresponding imide in good yield and tolerates a wide variety of functional groups and substituents on the oxazole moiety.