91824-00-9

Basic information

• Product Name: 2-(4-methyl-piperazin-1-yl)-cyclohexanol
• CAS NO: 91824-00-9
• Molecular Weight: 198.308
• Mol File: 91824-00-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-(4-methyl-piperazin-1-yl)-cyclohexanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methyl-piperazin-1-yl)-cyclohexanol(91824-00-9)
• EPA Substance Registry System: 2-(4-methyl-piperazin-1-yl)-cyclohexanol(91824-00-9)

Safety Data

• Hazardous Substances Data: 91824-00-9(Hazardous Substances Data)

Upstream product

• 109-01-3 1-methyl-piperazine 
• 286-20-4 cyclohexane-1,2-epoxide 

Downstream Products

• 802038-77-3 2-(4-methylpiperazin-1-yl)cyclohexanone 
• 102165-64-0 (+/-)-2-methoxy-benzoic acid-[trans-2-(4-methyl-piperazino)-cyclohexyl ester] 
• 108751-62-8 (+/-)-1-(trans-2-acetoxy-cyclohexyl)-4-methyl-piperazine; hydrochloride 
• 114331-37-2 (+/-)-4-nitro-benzoic acid-[trans-2-(4-methyl-piperazino)-cyclohexyl ester]; hydrochloride 
• 101715-45-1 (+/-)-1-(trans-2-benzoyloxy-cyclohexyl)-4-methyl-piperazine 
• 113454-89-0 (+/-)-3,4,5-trimethoxy-benzoic acid-[trans-2-(4-methyl-piperazino)-cyclohexyl ester] 

Relevant articles and documents

In vivo antifilarial activity of some cyclic and acylic alcohols

The filarial nematodes, Wuchereria bancrofti, Brugia malayi, and Brugia timori are the causative agents of lymphatic filariasis. 2-Substituted propanol, cyclohexanol, and cyclooctanol compounds were evaluated for microfilaricidal and macrofilaricidal activity in vivo against Acanthocheilonema viteae and Litomosoides carinii in rodents. In the cyclohexanol series, 2-(piperidin-1-yl) cyclohexanol (2b) showed 88.9% macrofilaricidal activity against A. viteae in vivo, while cyclooctanol series, 2-(4- benzyl piperdin-1-yl) cyclooctanol (2f) showed 100% macrofilaricidal activity against A. viteae. Further, compounds 1-(furan-2-ylamino) ethanol (4a) and 1-(4-benzylpiperidin- 1-yl)-ethyl acetate (5b) showed 81.3% and 83.4% macrofilaricidal activity, respectively, against the same parasite. Interestingly, compounds 2f and 4a showed significant sterilization of female worms in A. viteae. However, these compounds were found inactive against L. carinii. Therefore, the new class of compounds appeared to have promising antifilarial activity.

Amino alcohols in organocatalysed acylation and deacylation: The effect of dialkylamino substituents on the rate

In alcohols and esters, a neighbouring dialkylamino group can enhance the reactivity towards acylation and deacylation, respectively, that is, such amino alcohols can act as transacylation catalysts like DMAP. This effect is dependent on the number of (carbon) spacer atoms, flexibility of the molecule and the presence and position of further heteroatoms. Based on this effect, the site selective acylation and deacylation of desmycosin, a macrocycle antibiotic possessing an amino sugar moiety, is described.

Aminocyclohexylesters and uses thereof

Aminocyclohexylester compounds, including thioesters, are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and com