918327-55-6Relevant articles and documents
Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition
Trapp, Johannes,Jochum, Anne,Meier, Rene,Saunders, Laura,Marshall, Brett,Kunick, Conrad,Verdin, Eric,Goekjian, Peter,Sippl, Wolfgang,Jung, Manfred
, p. 7307 - 7316 (2006)
NAD+-dependent histone deacetylases, sirtuins, cleave acetyl groups from lysines of histones and other proteins to regulate their activity. Identification of potent selective inhibitors would help to elucidate sirtuin biology and could lead to