91840-94-7

Basic information

• Product Name: (R)-(-)-(E)-1,2-Diphenyl-2-(hydroxyimino)ethanol
• Synonyms: (R)-(-)-(E)-1,2-Diphenyl-2-(hydroxyimino)ethanol
• CAS NO: 91840-94-7
• Molecular Weight: 227.263
• Mol File: 91840-94-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (R)-(-)-(E)-1,2-Diphenyl-2-(hydroxyimino)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(-)-(E)-1,2-Diphenyl-2-(hydroxyimino)ethanol(91840-94-7)
• EPA Substance Registry System: (R)-(-)-(E)-1,2-Diphenyl-2-(hydroxyimino)ethanol(91840-94-7)

Safety Data

• Hazardous Substances Data: 91840-94-7(Hazardous Substances Data)

Upstream product

• 441-38-3 benzoin oxime 
• 5928-66-5 (R)-benzoin 
• 119-53-9 2-hydroxy-2-phenylacetophenone 
• 5928-67-6 (S)-(+)-benzoin 
• 118298-90-1 Trifluoro-acetic acid (S)-2-oxo-1,2-diphenyl-ethyl ester 
• 451-40-1 phenyl benzyl ketone 

Downstream Products

• 530-36-9 (1R,2R)-2-amino-1,2-diphenylethane-1-ol 
• 23190-16-1 (1R,2S)-2-Amino-1,2-diphenylethanol 
• 5928-66-5 (R)-benzoin 
• 23364-44-5 (1S,2R)-2-Amino-1,2-diphenylethanol 

Relevant articles and documents

Readily available ruthenium complex for efficient dynamic kinetic resolution of aromatic α-hydroxy ketones

A ruthenium complex formed from commercially available [Ru(p-cymene)Cl 2]2 and 1,4-bis(diphenylphosphino)butane catalyzes the racemization of aromatic α-hydroxy ketones very efficiently at room temperature. The racemization is fully compatible with a kinetic resolution catalyzed by a lipase from Pseudomonas stutzeri. This is the first example of dynamic kinetic resolution of α-hydroxy ketones at ambient temperature in which the metal and enzyme catalysts work in concert in one pot at room temperature to give quantitative yields of esters of α-hydroxy ketones with very high enantioselectivity.

Lipase TL-mediated kinetic resolution of benzoin: Facile synthesis of (1R,2S)-erythro-2-amino-1,2-diphenylethanol

The lipase TL-mediated kinetic resolution of (±)-benzoin (1) proceeded to give the corresponding optically pure benzoin (R)-1. On the other hand, (S)-benzoin-O-acetate (5) could be hydrolyzed without epimerization to give (S)-benzoin (S)-1, under alkaline conditions. Further, (R)-1 was converted to (1R,2S)-2-amino-1,2-diphenylethanol (99:1 er) according to the procedure reported previously. (C) 2000 Elsevier Science Ltd.

Asymmetric Synthesis of the Methyl and Benzyl Ethers of erythro-α,β-Diphenyl-β-hydroxyethanol and erythro-α,β-Diphenyl-β-hydroxyethylamine from (+)-(S)-Benzoin

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