918402-89-8Relevant articles and documents
Highly functionalized benzene syntheses by directed mono or multiple magnesiations with TMPMgCl·LiCl
Lin, Wenwei,Baron, Oliver,Knochel, Paul
, p. 5673 - 5676 (2007/10/03)
The direct magnesiation of highly functionalized aromatics bearing an ester, a nitrile, or a ketone can be readily performed by using an OBoc as a directing group and TMPMgCl·LiCl as a base. It allows, for example, the preparation of a meta-magnesiated benzophenone in >95%. After quenching, highly functionalized and substituted benzenes are obtained.