918431-94-4Relevant articles and documents
Design, synthesis, and evaluation of a novel 4-aminomethyl-4- fluoropiperidine as a T-type Ca2+ channel antagonist
Shipe, William D.,Barrow, James C.,Yang, Zhi-Qiang,Lindsley, Craig W.,Yang, F. Vivien,Schlegel, Kelly-Ann S.,Shu, Youheng,Rittle, Kenneth E.,Bock, Mark G.,Hartman, George D.,Tang, Cuyue,Ballard, Jeanine E.,Kuo, Yuhsin,Adarayan, Emily D.,Prueksaritanont, Thomayant,Zrada, Matthew M.,Uebele, Victor N.,Nuss, Cindy E.,Connolly, Thomas M.,Doran, Scott M.,Fox, Steven V.,Kraus, Richard L.,Marino, Michael J.,Graufelds, Valerie Kuzmick,Vargas, Hugo M.,Bunting, Patricia B.,Hasbun-Manning, Martha,Evans, Rose M.,Koblan, Kenneth S.,Renger, John J.
supporting information; scheme or table, p. 3692 - 3695 (2009/04/07)
The novel T-type antagonist (S)-5 has been prepared and evaluated in in vitro and in vivo assays for T-type calcium ion channel activity. Structural modification of the piperidine leads 1 and 2 afforded the fluorinated piperidine (S)-5, a potent and selec
