918483-35-9

Basic information

• Product Name: 4-iodo-1-(2,2,2-trifluoroethyl)-1H-pyrazole
• Synonyms: 4-iodo-1-(2,2,2-trifluoroethyl)-1H-pyrazole
• CAS NO: 918483-35-9
• Molecular Weight: 276
• Mol File: 918483-35-9.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 4-iodo-1-(2,2,2-trifluoroethyl)-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-iodo-1-(2,2,2-trifluoroethyl)-1H-pyrazole(918483-35-9)
• EPA Substance Registry System: 4-iodo-1-(2,2,2-trifluoroethyl)-1H-pyrazole(918483-35-9)

Safety Data

• Hazardous Substances Data: 918483-35-9(Hazardous Substances Data)

Usage

Uses

4-Iodo-1-(2,2,2-trifluoroethyl)-1H-pyrazole is a reactant in the preparation of orally bioavailable 1H-pyrrolo[3,2-c]pyridine inhibitors of mitotic kinase monopolar spindle 1 (MPS1).

Upstream product

• 3469-69-0 4-iodopyrazole 
• 6226-25-1 2,2,2-trifluoroethyl trifluoromethanesulphonate 
• 353-83-3 1,1,1-trifluoro-2-iodoethane 

Downstream Products

• 1400285-60-0 tert-butyl 6-(2-methoxyphenylamino)-2-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate 
• 1400286-43-2 N-(2-methoxyphenyl)-2-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine 
• 918483-50-8 4-[(3-bromophenyl)ethynyl]-1-(2,2,2-trifluoroethyl)-1H-pyrazole 

Relevant articles and documents

Pyrazole compound, medicine composition containing pyrazole compound and application

The invention relates to a pyrazole compound, a medicine composition containing the pyrazole compound and application. The pyrazole compound is of a structure shown in a formula (I) as shown in the description. The compound can be used for inhibiting IRAK

PEST CONTROL AGENT

PROBLEM TO BE SOLVED: To provide a compound highly active against pests. SOLUTION: The present invention provides a pest control agent comprising a compound represented by formula (I) or a salt thereof as an active ingredient, where A is a substitutable 5 membered heterocycle; R2 is halogen, hydroxyl, mercapto, cyano, nitro, alkyl, alkenyl, alkynyl, haloalkyl, alkoxy, alkenyloxy, alkynyloxy, alkylthio, haloalkoxy, alkenylthio, alkynylthio, NR3R4, alkylsulfinyl, alkenylsulfinyl, alkynylsulfinyl, alkylsulfonyl, alkenylsulfonyl, alkynylsulfonyl, alkoxyalkyl, alkylthioalkyl, alkylaminoalkyl, dialkylaminoalkyl, hydroxylalkyl, formyl or the like]. SELECTED DRAWING: None COPYRIGHT: (C)2016,JPO&INPIT

PYRROLOPYRIDINEAMINO DERIVATIVES AS MPS1 INHIBITORS

The present invention relates to the use of certain pyrrolopyridineamino derivatives (hereinafter referred to as “PPA derivatives”), particularly 1H-pyrrolo[3,2-c]pyridine-6-amino derivatives, to inhibit the spindle checkpoint function of Monospindle 1 (Mps1—also known as TTK) kinases either directly or indirectly via interaction with the Mps kinase itself. In particular, the present invention relates to PPA derivatives for use as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of the PPA derivatives, and pharmaceutical compositions comprising them. Formula (I)