918514-78-0

Basic information

• Product Name: 2-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine
• Synonyms: 2-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine;2-(trifluoroMethyl)-1H-pyrrolo[2,3
• CAS NO: 918514-78-0
• Molecular Formula: C₈H₅F₃N₂
• Molecular Weight: 186.1339096
• EINECS: -0
• Mol File: 918514-78-0.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Density: 1.447±0.06 g/cm3 (20 ºC 760 Torr)
• CAS DataBase Reference: 2-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine(918514-78-0)
• EPA Substance Registry System: 2-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine(918514-78-0)

Safety Data

• Hazardous Substances Data: 918514-78-0(Hazardous Substances Data)

Usage

General Description

2-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine is a chemical compound with a molecular formula C8H5F3N2. It is a heterocyclic compound that contains a pyrrole ring fused to a pyridine ring, and it also has a trifluoromethyl group attached to the pyrrole ring. 2-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine is commonly used in organic synthesis and medicinal chemistry as a building block for creating various molecules and pharmaceuticals. It possesses unique physicochemical properties due to the presence of the trifluoromethyl group, making it a valuable tool for drug discovery and development. Additionally, the trifluoromethyl group can enhance the biological activity and metabolic stability of drug candidates, making this compound an important constituent in the design and development of new drugs.

Upstream product

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Downstream Products

• 1014614-13-1 4-[2-(difluoromethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-N-(1,1-dioxidotetrahydro-3-thienyl)benzenesulfonamide 
• 1014613-16-1 4-chloro-2-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine 
• 1187323-24-5 N-(tetrahydro-2H-thiopyran-4-yl)-4-[2-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]benzenesulfonamide 
• 1187323-29-0 N-(1-oxidotetrahydro-2H-thiopyran-4-yl)-4-[2-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]benzenesulfonamide formate 
• 1187323-27-8 N-(1-oxidotetrahydro-2H-thiopyran-4-yl)-4-[2-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]benzenesulfonamide trifluoroacetate 

Relevant articles and documents

Metal-free oxidative trifluoromethylation of indoles with CF3SO2Na on the C2 position

An efficient method of synthesizing 2-trifluoromethylindoles from indoles with easy-to-handle, cheap and low-toxic CF3SO2Na under metal-free conditions is described, which selectively introduces trifluoromethyl to indoles on the C2 position. The desired product can be obtained in 0.7 g yield. A radical intermediate may be involved in this transformation.

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