91869-09-9

Basic information

• Product Name: Benzenepentanoyl chloride, 3,4-dimethoxy-
• CAS NO: 91869-09-9
• Molecular Formula: C13H17ClO3
• Molecular Weight: 256.729
• Mol File: 91869-09-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzenepentanoyl chloride, 3,4-dimethoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepentanoyl chloride, 3,4-dimethoxy-(91869-09-9)
• EPA Substance Registry System: Benzenepentanoyl chloride, 3,4-dimethoxy-(91869-09-9)

Safety Data

• Hazardous Substances Data: 91869-09-9(Hazardous Substances Data)

Upstream product

• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 874518-45-3 5-(3,4-dimethoxyphenyl)pentanoic acid ethyl ester 
• 101619-71-0 (2E,4E)-ethyl 5-(3,4-dimethoxyphenyl)penta-2,4-dienoate 
• 1145-15-9 5-(3,4-dimethoxyphenyl)pentanoic acid 

Downstream Products

• 1452406-10-8 6-(3,4-dimethoxyphenyl)-1,1,1-trifluorohexan-2-one 
• 1452406-19-7 7-(3,4-dimethoxyphenyl)-1,1,1,2,2-pentafluoroheptan-3-one 
• 64648-01-7 N-Chloroacetyl-5-(3,4-dimethoxyphenyl)pentylamine 
• 91869-10-2 1-<5-<3,4-Bis(trimethylsilyloxy)phenyl>-1-oxopentyl>-4-trimethylsilyloxypiperidin 
• 91869-11-3 5-(3,4-Dihydroxy-phenyl)-1-(4-hydroxy-piperidin-1-yl)-pentan-1-one 
• 436155-60-1 methyl 2-[5-(3,4-dimethoxyphenyl)pentanoyl]hydrazinecarboxylate 
• 77775-67-8 5-(3,4-dimethoxyphenyl)valeramide 
• 91887-07-9 1-<5-(3,4-Dimethoxyphenyl)-1-oxopentyl>-4-hydroxypiperidin 
• 91887-06-8 1-<5-(3,4-Dimethoxyphenyl)-1-oxopentyl>piperidin 

Relevant articles and documents

Intramolecular Friedel-Crafts Acylation Reaction Promoted by 1,1,1,3,3,3-Hexafluoro-2-propanol

Simple dissolution of an arylalkyl acid chloride in 1,1,1,3,3,3-hexafluoro-2-propanol promotes an intramolecular Friedel-Crafts acylation without additional catalysts or reagents. This reaction is operationally trivial in both execution and product isolation (only requiring concentration followed by purification) and accommodates a broad range of substrates. Preliminary studies that bear upon potential reaction mechanisms are reported.

Intramolecular addition of acyldiazenecarboxylates onto double bonds in the synthesis of heterocycles

Appropriate aryl-substituted unsymmetrical azodicarbonyl compounds, generated from bishydrazides by oxidation, undergo intramolecular cyclisations to furnish a variety of useful heterocycles such as N-substituted oxindoles, carbostyrils, benzazepinones, benzazocinones, benzimidazolones, benzoxazinones and pyrazolones in varying degrees of efficiency. Methods are described to remove the N-acyl groups from the heteroaromatic compounds. Under mildly acidic conditions where equal opportunities are available for an ipso or a normal cyclisation it is the former process that occurs preferentially. Evidence is presented in favour of a C-to-C migration in the ipso product for the formation of a methoxy-substituted carbostyril derivative. One of the spiro substances is shown to participate in dienone-phenol rearrangement to provide the corresponding quinolone-phenol in high yield.