91873-05-1Relevant articles and documents
COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE
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Page/Page column 209, (2019/01/06)
The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted bicyclic heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.
SYNTHESIS OF INDOLE AND RELATED COMPOUNDS FROM HALO-NITROAROMATICS
Sakamoto, Takao,Yoshinori, Kondo,Yamanaka, Hiroshi
, p. 1347 - 1350 (2007/10/02)
5,7-dimethyl-6-azaindole was synthesized by treatment of 3-amino-2,6-dimethyl-4-pyridineacetaldehyde diethyl acetal with hydrochloric acid in boiling ethanol.According to the similar manner, indole and ethyl 4-indolecarboxylate were obtained from the corresponding 2-aminophenylacetaldehyde derivatives in satisfactory yields.The starting materials were easily prepared by palladium-catalyzed cross-coupling reaction of o-halonitroaromatics with trimethylsilylacetylene followed by the reaction with sodium ethoxide and catalytic reduction of the o-nitro group.