918867-88-6 Usage
Description
TaMsulosin EP IMpurity A, also known as N-[2-(2-Ethoxyphenoxy)ethyl]-(R)-Tamsulosin, is a chemical compound derived from 5-[(2R)-2-Aminopropyl]-2-methoxybenzenesulfonamide (A628695), which is a precursor in the synthesis of TaMsulosin (T006350) and other alpha-andregenic antagonists. It is a specific α1-adrenoceptor antagonist.
Uses
Used in Pharmaceutical Industry:
TaMsulosin EP IMpurity A is used as an intermediate in the synthesis of TaMsulosin, a specific α1-adrenoceptor antagonist, for the treatment of benign prostatic hypertrophy. It plays a crucial role in the development and production of medications targeting prostate-related conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 918867-88-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,8,8,6 and 7 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 918867-88:
(8*9)+(7*1)+(6*8)+(5*8)+(4*6)+(3*7)+(2*8)+(1*8)=236
236 % 10 = 6
So 918867-88-6 is a valid CAS Registry Number.
918867-88-6Relevant articles and documents
PROCESS FOR THE PREPARATION OF TAMSULOSIN
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Page/Page column 17-18, (2010/11/25)
The invention includes an improved process for producing tamsulosin comprising reacting 5-(2-aminopropyl)-2-methoxybenzenesulfonamide with 2-(o-ethoxyphenoxy)ethyl bromide in an organic phosphite solvent to obtain tamsulosin. Optically pure (R)- 5-(2-aminopropyl)-2- methoxybenzenesulfonamide can be employed to produce optically pure (R)-tamsulosin product. The organic phosphite solvent utilized in the reaction can include tri-alkyl phosphites such as triethyl phosphite, trimethyl phosphite, and tributyl phosphite. Additionally, processes for producing tamsulosin having a low concentration of by-product contaminants, such as 5-((R)-2- {Bis-[2-(2-ethoxyphenoxy)ethyl]amino}-propyl)-2-methoxybenzenesulfonamide, and the use of such by-products to monitor the chemical purity of tamsulosin, are provided.