918902-48-4

Basic information

• Product Name: L-Phenylalanine, N,1-bis[(1,1-dimethylethoxy)carbonyl]-L-tryptophyl-, methyl ester
• CAS NO: 918902-48-4
• Molecular Formula: C31H39N3O7
• Molecular Weight: 565.667
• Mol File: 918902-48-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: L-Phenylalanine, N,1-bis[(1,1-dimethylethoxy)carbonyl]-L-tryptophyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Phenylalanine, N,1-bis[(1,1-dimethylethoxy)carbonyl]-L-tryptophyl-, methyl ester(918902-48-4)
• EPA Substance Registry System: L-Phenylalanine, N,1-bis[(1,1-dimethylethoxy)carbonyl]-L-tryptophyl-, methyl ester(918902-48-4)

Safety Data

• Hazardous Substances Data: 918902-48-4(Hazardous Substances Data)

Upstream product

• 144599-95-1 N^α-(tert-butoxycarbonyl)-1-methyl-L-tryptophan 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 

Downstream Products

• 918902-51-9 Boc-Trp(Boc)-Phe-OH 
• 918902-56-4 C₃₀H₃₆N₃O₆(NHC₄H₅OO) 
• 82597-82-8 cyclo(L-tryptophyl-L-phenylalanyl) 
• 198632-67-6 (S)-2-[(S)-2-Amino-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionic acid methyl ester 

Relevant articles and documents

A Mutasynthesis Approach with a Penicillium chrysogenum ΔroqA Strain Yields New Roquefortine D Analogues

Penicillium chrysogenum, which lacks the roqA gene, processes synthetic, exogenously added histidyltryptophanyldiketopiperazine (HTD) to yield a set of roquefortine-based secondary metabolites also produced by the wild-type strain. Feeding a number of synthetic HTD analogues to the ΔroqA strain gives rise to the biosynthesis of a number of new roquefortine D derivatives, depending on the nature of the synthetic HTD added. Besides delivering semisynthetic roquefortine analogues, the mutasynthesis studies presented here also shed light on the substrate preferences and molecular mechanisms employed by the roquefortine C/D biosynthesis gene cluster, knowledge that may be tapped for the future development of more complex semisynthetic roquefortine-based secondary metabolites.