918967-52-9

Basic information

• Product Name: TERT-BUTYL 4-(N-HYDROXYCARBAMIMIDOYL)-PHENYLCARBAMATE
• Synonyms: TERT-BUTYL 4-(N-HYDROXYCARBAMIMIDOYL)-PHENYLCARBAMATE
• CAS NO: 918967-52-9
• Molecular Formula: C₁₂H₁₇N₃O₃
• Molecular Weight: 251.28168
• Mol File: 918967-52-9.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: TERT-BUTYL 4-(N-HYDROXYCARBAMIMIDOYL)-PHENYLCARBAMATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL 4-(N-HYDROXYCARBAMIMIDOYL)-PHENYLCARBAMATE(918967-52-9)
• EPA Substance Registry System: TERT-BUTYL 4-(N-HYDROXYCARBAMIMIDOYL)-PHENYLCARBAMATE(918967-52-9)

Safety Data

• Hazardous Substances Data: 918967-52-9(Hazardous Substances Data)

Upstream product

• 143090-18-0 tert-butyl N-(4-cyanophenyl)carbamate 
• 873-74-5 4-Aminobenzonitrile 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 10185-68-9 4-(5-methyl-1,2,4-oxadiazol-3-yl)-aniline 
• 643744-95-0 [4-(5-methyl-[1,2,4]oxadiazol-3-yl)-phenyl]-carbamic acid tert-butyl ester 
• 643744-96-1 [4-(5-methyl-[1,2,4]oxadiazol-3-yl)-phenyl]-carbamic acid benzyl ester 
• 24990-21-4 4,5-dihydro-[1,2,4]oxadiazole 
• 1181215-02-0 {4-[5-(4-trifluoromethoxyphenyl)-[1,2,4]oxadiazol-3-yl]-phenyl}-carbamic acid tert-butyl ester 

Relevant articles and documents

Development of Potent 3-Br-isoxazoline-Based Antimalarial and Antileishmanial Compounds

Starting from the structure of previously reported 3-Br-isoxazoline-based covalent inhibitors of P. falciparum glyceraldehyde 3-phosphate dehydrogenase, and with the intent to improve their metabolic stability and antimalarial activity, we designed and synthesized a series of simplified analogues that are characterized by the insertion of the oxadiazole ring as a bioisosteric replacement for the metabolically labile ester/amide function. We then further replaced the oxadiazole ring with a series of five-membered heterocycles and finally combined the most promising structural features. All the new derivatives were tested in vitro for antimalarial as well as antileishmanial activity. We identified two very promising new lead compounds, endowed with submicromolar antileishmanial activity and nanomolar antiplasmodial activity, respectively, and a very high selectivity index with respect to mammalian cells.

Room-temperature synthesis of pharmaceutically important carboxylic acids bearing the 1,2,4-oxadiazole moiety

An efficient and mild one-pot protocol has been developed for the synthesis of 1,2,4-oxadiazoles via the reaction of amidoximes with dicarboxylic acid anhydrides in a NaOH/DMSO medium. The method allows the synthesis of diversely substituted carboxylic acids bearing the 1,2,4-oxadiazole motif, – a popular building block for pharmaceutical research, in moderate to excellent yields. The reaction scope includes aromatic and heteroaromatic amidoximes as well as five-, six- and seven-membered anhydrides. The advantages of this procedure are proven gram-scalability and the use of inexpensive starting materials, which from a process chemistry point of view are essential for future industrial applications.

BIFUNCTIONAL COMPOUNDS AND USE FOR REDUCING URIC ACID LEVELS

Bifunctional compounds that increase uric acid excretion and reduce uric acid production, and monofunctional compounds that either increase uric acid excretion or reduce uric acid production. Methods of using these compounds for reducing uric acid levels