919119-72-5 Usage
Description
1H-Indole, 2,7-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)is a chemical compound that is commonly used in organic synthesis. It is a derivative of 1H-indole, which is a heterocyclic compound that is widely used as a building block in the synthesis of pharmaceuticals, agrochemicals, and functional materials. The presence of two 4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl groups in this compound makes it useful as a reagent for cross-coupling reactions, particularly in palladium-catalyzed reactions. 1H-Indole, 2,7-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)is a versatile and valuable building block in organic chemistry due to its reactivity and ability to participate in a wide range of synthetic transformations.
Uses
Used in Pharmaceutical Industry:
1H-Indole, 2,7-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)is used as a building block for the synthesis of pharmaceuticals for its ability to participate in cross-coupling reactions, which allows for the creation of a variety of complex molecules with potential therapeutic properties.
Used in Agrochemical Industry:
1H-Indole, 2,7-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)is used as a building block for the synthesis of agrochemicals for its reactivity in cross-coupling reactions, enabling the development of new compounds with pesticidal or herbicidal activity.
Used in Functional Materials Industry:
1H-Indole, 2,7-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)is used as a building block for the synthesis of functional materials for its versatility in organic chemistry, allowing for the creation of materials with specific properties for various applications.
Check Digit Verification of cas no
The CAS Registry Mumber 919119-72-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,9,1,1 and 9 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 919119-72:
(8*9)+(7*1)+(6*9)+(5*1)+(4*1)+(3*9)+(2*7)+(1*2)=185
185 % 10 = 5
So 919119-72-5 is a valid CAS Registry Number.
919119-72-5Relevant articles and documents
Noncovalent Interactions in Ir-Catalyzed C-H Activation: L-Shaped Ligand for Para-Selective Borylation of Aromatic Esters
Hoque, Md Emdadul,Bisht, Ranjana,Haldar, Chabush,Chattopadhyay, Buddhadeb
supporting information, p. 7745 - 7748 (2017/06/21)
An efficient strategy for the para-selective borylation of aromatic esters is described. For achieving high para-selectivity, a new catalytic system has been developed modifying the core structure of the bipyridine. It has been proposed that the L-shaped ligand is essential to recognize the functionality of the oxygen atom of the ester carbonyl group via noncovalent interaction, which provides an unprecedented controlling factor for para-selective C-H activation/borylation.
Iridium-catalyzed, silyl-directed borylation of nitrogen-containing heterocycles
Robbins, Daniel W.,Boebel, Timothy A.,Hartwig, John F.
scheme or table, p. 4068 - 4069 (2010/05/01)
Chemical Figure Presented Selective methods for the functionalization of indoles and other nitrogen heterocycles would provide access to the core structures of many natural products and pharmaceuticals. Although there are many methods and strategies for the synthesis of substituted indoles or functionalization of the azole ring, strategies for the selective functionalization of the benzo-fused portion of the indole skeleton, particularly the 7-position, are less common. We report a one-pot, iridium-catalyzed, silyl-directed C-H borylation of indoles at the 7-position. This process occurs in high yield with a variety of substituted indoles, and conversions of the 7-borylindole products to 7-aryl-, 7-cinnamyl-, and 7-haloindoles are demonstrated. The lr-catalyzed, silyl-directed C-H borylation also occurs with several other nitrogen heterocycles, including carbazole, phenothiazines, and tetrahydroquinoline. The utility of this methodology is highlighted by the one-pot synthesis of a member of the pyrrolophenanthrldone class of alkaloid natural products. Copyright
