91914-04-4

Basic information

• Product Name: 2-HYDROXY-3-METHYLPYRIDINE
• Synonyms: 3-METHYLPYRIDIN-2-OL;3-METHYL-2-HYDROXYPYRIDINE;1-METHYL-2-HYDROXYPYRIDINE;3-METHYL-2-HYDROXYPYRIDINE 98+%
• CAS NO: 91914-04-4
• Molecular Formula: C₆H₇NO
• Molecular Weight: 109.13
• EINECS: 213-710-2
• Product Categories: Pyrazine
• Mol File: 91914-04-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 139-141℃
• Boiling Point: 307.4°C at 760 mmHg
• Flash Point: 172.7°C
• Appearance: /
• Density: 1.053g/cm³
• Vapor Pressure: 0.000724mmHg at 25°C
• Refractive Index: 1.499
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 10.37±0.10(Predicted)
• CAS DataBase Reference: 2-HYDROXY-3-METHYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY-3-METHYLPYRIDINE(91914-04-4)
• EPA Substance Registry System: 2-HYDROXY-3-METHYLPYRIDINE(91914-04-4)

Safety Data

• Hazard Codes: Xn:Harmful
• Statements: R22:; R37/38:; R41:
• Safety Statements: S26:; S36:
• Hazardous Substances Data: 91914-04-4(Hazardous Substances Data)

Usage

General Description

2-Hydroxy-3-methylpyridine is a chemical compound with the molecular formula C6H7NO. It is a derivative of pyridine, containing a hydroxyl group and a methyl group attached to the pyridine ring. This chemical is mainly used as a building block in the synthesis of pharmaceuticals and agrochemicals. It is also known for its role as a ligand in coordination chemistry and as a precursor in the production of specialty chemicals. Due to its structure, 2-Hydroxy-3-methylpyridine exhibits a range of chemical and biological activities, which make it useful in various industrial applications. However, it is important to handle this chemical with care, as it may pose health and environmental hazards if not properly managed.

InChI:InChI=1/C6H7NO/c1-5-3-2-4-7-6(5)8/h2-4H,1H3,(H,7,8)

Upstream product

• 1603-40-3 3-methylpyridin-2-ylamine 
• 1006-97-9 3-methylpyridin-2-yl acetate 
• 7647-01-0 hydrogenchloride 
• 2369-18-8 2-fluoro-3-methylpyridine 
• 108-99-6 3-Methylpyridine 
• 1603-41-4 (5-methyl-pyridin-2-yl)amine 

Downstream Products

• 18368-76-8 2 chloro-3-methylpyridine 
• 857436-24-9 3-methyl-5-trityl-pyridin-2-ol 
• 856965-73-6 5-(biphenyl-4-yl-diphenyl-methyl)-3-methyl-pyridin-2-ol 
• 3430-17-9 2-bromo-3-picoline 
• 58498-61-6 5-chloro-3-methylpyridin-2-ol 
• 18368-66-6 2-thiol-3-methylpyridine 
• 21901-34-8 2-hydroxy-3-methyl-5-nitropyridine 
• 857434-35-6 2-chloro-3-methyl-5-trityl-pyridine 
• 1762-32-9 3,3'-dimethyl-2,2'-bipyridine 
• 755031-65-3 3-(3-methoxy-4-nitrophenyl)-8-[2-(3-methyl-2-oxopyridin-1(2H)-yl)ethyl]-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one 
• 1003-68-5 5-methyl-pyridin-2-ol 
• 154447-02-6 3-methylpyridin-2-yl trifluoromethanesulfonate 
• 1174281-25-4 3-methylpyridin-2-yl 4-methylbenzenesulfonate 
• 1093656-50-8 1-(5-chloro-2-methyl-4-nitrophenyl)-3-methyl-pyridin-2(1H)-one 

Relevant articles and documents

(Methylsulfonyl)phenyl-2-(5H)-furanones as COX-2 inhibitors

The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. STR1 The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.

3,4-diaryl-2-hydroxy-2,5-dihydrofurans as prodrugs to COX-2 inhibitors

The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. STR1 The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.

VERSATILE SYNTHESIS OF AN INTERMEDIATE FOR THE 1β-METHYLCARBAPENEM SYNTHESIS

A 1β-methylcarboxylate (1) which is a requisite intermediate for the synthesis of the 1β-methylcarbapenem was obtained in an efficient manner by the coupling reaction of a Z(O)-pyridylthiosilyl enol ether and a 4-acetoxyazetidinone derivative in the presence of ZnCl2 in CH2Cl2.The reactive silyl enol ether was prepared by the reverse addition method in high yield.