919295-69-5Relevant articles and documents
Discovery and refinement of a new structural class of potent peptide deformylase inhibitors
Boularot, Adrien,Giglione, Carmela,Petit, Sylvain,Duroc, Yann,De Sousa, Rodolphe Alves,Larue, Valéry,Cresteil, Thierry,Dardel, Frédéric,Artaud, Isabelle,Meinnel, Thierry
, p. 10 - 20 (2007)
New classes of antibiotics are urgently needed to counter increasing levels of pathogen resistance. Peptide deformylase (PDF) was originally selected as a specific bacterial target, but a human homologue, the inhibition of which causes cell death, was rec