91968-72-8

Basic information

• Product Name: 2-Propanol, 2-Methyl-1-(phenylMethoxy)-
• Synonyms: 2-Propanol, 2-Methyl-1-(phenylMethoxy)-;1-(Benzyloxy)-2-Methylpropan-2-ol
• CAS NO: 91968-72-8
• Molecular Formula: C₁₁H₁₆O₂
• Molecular Weight: 180.24354
• Mol File: 91968-72-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Propanol, 2-Methyl-1-(phenylMethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propanol, 2-Methyl-1-(phenylMethoxy)-(91968-72-8)
• EPA Substance Registry System: 2-Propanol, 2-Methyl-1-(phenylMethoxy)-(91968-72-8)

Safety Data

• Hazardous Substances Data: 91968-72-8(Hazardous Substances Data)

Usage

General Description

2-Propanol, 2-methyl-1-(phenylmethoxy)- is a chemical compound that is also known as isopropyl ether. It is a colorless and flammable liquid with a mild, ether-like odor. 2-Propanol, 2-methyl-1-(phenylmethoxy)- is commonly used as a solvent in various industrial applications and as a fuel for camp stoves and lanterns. It is also used as an intermediate in the production of other chemicals. However, it is important to handle this chemical with care as it can be harmful if ingested or inhaled, and can cause irritation to the skin and eyes. Proper safety precautions and handling procedures should be followed when working with 2-Propanol, 2-methyl-1-(phenylmethoxy)-.

Upstream product

• 917-64-6 methyl magnesium iodide 
• 32122-09-1 ethyl benzyloxyacetate 
• 22539-93-1 3-benzyloxypropanone 
• 2999-74-8 dimethylmagnesium 
• 16721-45-2 triphenyl(phenylmethylene)phosphorane 
• 558-30-5 2-methyl-1,2-epoxypropane 
• 100-51-6 benzyl alcohol 

Downstream Products

• 1479084-85-9 3-((1-(benzyloxy)-2-methylpropan-2-yloxy)methyl)-1H-pyrazole 

Relevant articles and documents

PYRAZOLE AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS FOR USE IN THE TREATMENT OF PARKINSON'S DISEASE

Compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3 and A are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease

Chelates as intermediates in nucleophilic additions to alkoxy ketones according to Cram's rule (cyclic model)

Chelates have been considered intermediates in the often highly stereoselective reactions of α-alkoxy and similarly substituted ketones for over 30 years,10 but without mechanistic evidence. It is now shown, by stop-flow ("rapid injection") NMR kinetics,15 that the specific rates of reaction of ketones C6H5COCH(OR)CH3 with Me2Mg, where R = (i-Pr)3 ("TIPS"), t-BuPh2Si, t-BuMe2Si, Et3Si, Me3Si, and Me, parallel the diastereoselectivity of the reaction; i.e., the fastest reacting compound (R = Me) is the one which gives the highest proportion of the product predicted by Cram's chelate rule. The major product of the slowest reacting compound (R = TIPS) is not in accord with Cram's chelate rule, and this compound reacts at the same specific rate as the parent, C6H5COCH2CH3. This is in accord with earlier work indicating that TIPSO does not chelate. Compounds intermediate in the series react at intermediate rates and give the two diastereomeric products in proportions which can be calculated by assuming two competing reactions (cf. Figure 2): one proceeding via the chelated transition states giving the product predicted by the chelate rule and one not involving chelation which gives the same product composition as the R = TIPS compound. Direct steric effects on carbonyl reactivity due to the remote bulky silyloxy substituents have been excluded by the study of carbon analogues bearing similar bulky groups. Thus, the kinetic effect in the above series appears to be due to steric hindrance to chelation; hence, the parallel of specific rate and stereoselectivity demonstrates that high stereoselectivity is associated with strong chelation, as postulated by Cram and Kopecky in 1959.10.