920302-12-1Relevant articles and documents
Discovery and biological evaluation of benzo[a]carbazole-based small molecule agonists of the thrombopoietin (Tpo) receptor
Alper, Phil B.,Marsilje, Thomas H.,Mutnick, Daniel,Lu, Wenshuo,Chatterjee, Arnab,Roberts, Michael J.,He, Yun,Karanewsky, Donald S.,Chow, Donald,Lao, Jianmin,Gerken, Andrea,Tuntland, Tove,Liu, Bo,Chang, Jonathan,Gordon, Perry,Martin Seidel,Tian, Shin-Shay
body text, p. 5255 - 5258 (2009/05/07)
A novel series of benzo[a]carbazole-based small molecule agonists of the thrombopoietin (Tpo) receptor is reported. Starting from a 3.4 μM high throughput screen hit, members of this series have been identified which are full agonists with functional potency 50 nM and oral bioavailability in mice.
